ID B7LIE0_ECO45 Unreviewed; 402 AA.
AC B7LIE0;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Type I secretion membrane-fusion protein EtsA {ECO:0000313|EMBL:CAQ87208.1};
GN Name=etsA {ECO:0000313|EMBL:CAQ87208.1};
GN ORFNames=ECS88_p0148 {ECO:0000313|EMBL:CAQ87208.1};
OS Escherichia coli O45:K1 (strain S88 / ExPEC).
OG Plasmid pECOS88 {ECO:0000313|EMBL:CAQ87208.1,
OG ECO:0000313|Proteomes:UP000000747}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585035 {ECO:0000313|EMBL:CAQ87208.1, ECO:0000313|Proteomes:UP000000747};
RN [1] {ECO:0000313|Proteomes:UP000000747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S88 / ExPEC {ECO:0000313|Proteomes:UP000000747};
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CU928146; CAQ87208.1; -; Genomic_DNA.
DR AlphaFoldDB; B7LIE0; -.
DR KEGG; ecz:ECS88_p0148; -.
DR Proteomes; UP000000747; Plasmid pECOS88.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Plasmid {ECO:0000313|EMBL:CAQ87208.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000747}.
FT DOMAIN 55..270
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT COILED 106..188
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 402 AA; 44371 MW; 7DE9EB81421D0E3C CRC64;
MLWKTWTMLM KYISHRAIIC TLTLLIIIIT VLFTFLRSSD VPEYITAPVR KGDIENSVLA
TGRIDAIERV NVGAQVSGQL KSLKVKQGDH VTKGQLIAEI DDLPQCNDLR NAEAALNEVK
AELQSKQALL KQAELRFKRQ LRMLRENASS HEDFESAEAM LATTRAELHS LNAKLVQAQI
EVDKKKLALE YTRVVAPMDG IVIAIVTQQG QTVNSNQSAP TIIKLARLDV MTIKAQISEA
DITRISVGQK ARFSIFSEPD KHYSATLRAV ELAPESVMKD DSLASNTSAS GSGTSNASVY
YNALFDVPNP ENRLRIAMTA QVTLITDEAQ NTLLVPIQAV HRNEGKKQQV LVLAADGRLE
PRNVKTGITN SVDIQILEGL NVGENVVLSL PDKKEPEERI ML
//
