ID B7MN91_ECO45 Unreviewed; 418 AA.
AC B7MN91;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=N-acylneuraminate cytidylyltransferase {ECO:0000313|EMBL:CAR04562.1};
DE EC=2.7.7.43 {ECO:0000313|EMBL:CAR04562.1};
GN Name=neuA {ECO:0000313|EMBL:CAR04562.1};
GN OrderedLocusNames=ECS88_3329 {ECO:0000313|EMBL:CAR04562.1};
OS Escherichia coli O45:K1 (strain S88 / ExPEC).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585035 {ECO:0000313|EMBL:CAR04562.1, ECO:0000313|Proteomes:UP000000747};
RN [1] {ECO:0000313|Proteomes:UP000000747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S88 / ExPEC {ECO:0000313|Proteomes:UP000000747};
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
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DR EMBL; CU928161; CAR04562.1; -; Genomic_DNA.
DR RefSeq; WP_001259305.1; NC_011742.1.
DR AlphaFoldDB; B7MN91; -.
DR KEGG; ecz:ECS88_3329; -.
DR HOGENOM; CLU_660110_0_0_6; -.
DR Proteomes; UP000000747; Chromosome.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0008781; F:N-acylneuraminate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd02513; CMP-NeuAc_Synthase; 1.
DR CDD; cd01841; NnaC_like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR003329; Cytidylyl_trans.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR21485; HAD SUPERFAMILY MEMBERS CMAS AND KDSC; 1.
DR PANTHER; PTHR21485:SF3; N-ACYLNEURAMINATE CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF02348; CTP_transf_3; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:CAR04562.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000747};
KW Transferase {ECO:0000313|EMBL:CAR04562.1}.
FT DOMAIN 270..407
FT /note="SGNH hydrolase-type esterase"
FT /evidence="ECO:0000259|Pfam:PF13472"
SQ SEQUENCE 418 AA; 48621 MW; 44848B82016D0510 CRC64;
MRTKIIAIIP ARSGSKGLRN KNALMLIDKP LLAYTIEAAL QSEMFEKVIV TTDSEQYGAI
AESYGADFLL RPEELATDKA SSFEFIKHAL SIYTDYESFA LLQPTSPFRD STHIIEAVKL
YQTLEKYQCV VSVTRSNKPS QIIRPLDDYS TLSFFDLDYS KYNRNSIVEY HPNGAIFIAN
KQHYLHTKHF FGRYSLAYIM DKESSLDIDD RMDFELAITI QQKKNRQKIL YQNIHNRINE
KRNEFDSVSD ITLIGHSLFD YWDVKKINDI EVNNLGIAGI NSKEYYEYII EKELIVNFGE
FVFIFFGTND IVVSDWKKED TLWYLKKTCQ YIKKKNAASK IYLLSVPPVF GRIDRDNRII
NDLNSYLREN VDFAKFISLD HVLKDSYGNL NKMYTYDGLH FNSNGYTVLE NEIAEIVK
//
