ID B7N1M8_ECO81 Unreviewed; 331 AA.
AC B7N1M8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=DNA-binding transcriptional repressor {ECO:0000313|EMBL:CAR10248.2};
GN Name=gntR {ECO:0000313|EMBL:CAR10248.2};
GN OrderedLocusNames=ECED1_4112 {ECO:0000313|EMBL:CAR10248.2};
OS Escherichia coli O81 (strain ED1a).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585397 {ECO:0000313|EMBL:CAR10248.2, ECO:0000313|Proteomes:UP000000748};
RN [1] {ECO:0000313|Proteomes:UP000000748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ED1a {ECO:0000313|Proteomes:UP000000748};
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
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DR EMBL; CU928162; CAR10248.2; -; Genomic_DNA.
DR RefSeq; WP_000730252.1; NC_011745.1.
DR AlphaFoldDB; B7N1M8; -.
DR SMR; B7N1M8; -.
DR GeneID; 75059978; -.
DR KEGG; ecq:ECED1_4112; -.
DR HOGENOM; CLU_037628_6_3_6; -.
DR Proteomes; UP000000748; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd01575; PBP1_GntR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR001761; Peripla_BP/Lac1_sug-bd_dom.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF2; HTH-TYPE TRANSCRIPTIONAL REGULATOR GNTR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF00532; Peripla_BP_1; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000313|EMBL:CAR10248.2};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..60
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
FT DOMAIN 8..50
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
SQ SEQUENCE 331 AA; 36422 MW; 5A40666364E0C896 CRC64;
MKKKRPVLQD VADRVGVTKM TVSRFLRNPE QVSVALRGKI AAALDELGYI PNRAPDILSN
ATSRAIGVLL PSLTNQVFAE VLRGIESVTD AHGYQTMLAH YGYKPEMEQE RLESMLSWNI
DGLILTERTH TPRTLKMIEV AGIPVVELMD SKSPCLDIAV GFDNFEAARQ MTTAIIARGH
RHIAYLGARL DERTIIKQKG YEQAMLDAGL VPYSVMVEQS SSYSSGIELI RQARREYPQL
DGVFCTNDDL AVGAAFECQR LGLKVPDDMA IAGFHGHDIG QVMEPRLASV LTPRERMGSI
GAERLLARIR GESVTPKMLD LGFTLSPGGS I
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