ID B7NZG8_RABIT Unreviewed; 497 AA.
AC B7NZG8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=E3 ubiquitin-protein ligase XIAP {ECO:0000256|ARBA:ARBA00044089};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=Baculoviral IAP repeat-containing protein 4 {ECO:0000256|ARBA:ARBA00044214};
DE AltName: Full=RING-type E3 ubiquitin transferase XIAP {ECO:0000256|ARBA:ARBA00044244};
DE AltName: Full=X-linked inhibitor of apoptosis protein {ECO:0000256|ARBA:ARBA00044224};
GN Name=XIAP {ECO:0000313|EMBL:ACJ76605.1};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|EMBL:ACJ76605.1};
RN [1] {ECO:0000313|EMBL:ACJ76605.1}
RP NUCLEOTIDE SEQUENCE.
RA Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA Tsipouri V., Young A., Green E.D.;
RT "NISC Comparative Sequencing Initiative.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR EMBL; DP001040; ACJ76605.1; -; Genomic_DNA.
DR RefSeq; NP_001164796.1; NM_001171325.1.
DR RefSeq; XP_008271260.1; XM_008273038.2.
DR AlphaFoldDB; B7NZG8; -.
DR GeneID; 100328700; -.
DR KEGG; ocu:100328700; -.
DR CTD; 331; -.
DR eggNOG; KOG1101; Eukaryota.
DR HOGENOM; CLU_016347_1_1_1; -.
DR OMA; CMDENIA; -.
DR OrthoDB; 383715at2759; -.
DR TreeFam; TF105356; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043067; P:regulation of programmed cell death; IEA:UniProt.
DR CDD; cd00022; BIR; 3.
DR CDD; cd16714; RING-HC_BIRC4_8; 1.
DR CDD; cd14395; UBA_BIRC4_8; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR048875; BIRC2-3-like_UBA.
DR InterPro; IPR042579; XIAP/BIRC8_UBA.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10044:SF115; E3 UBIQUITIN-PROTEIN LIGASE XIAP; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 3.
DR Pfam; PF21290; BIRC2-3-like_UBA; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 3.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 3.
DR PROSITE; PS01282; BIR_REPEAT_1; 2.
DR PROSITE; PS50143; BIR_REPEAT_2; 3.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 450..484
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 497 AA; 56506 MW; 22E6E55DD921E2B3 CRC64;
MTFNSFEGSK TCVPADINKD EEFVEEFNRL KTFANFPSSS PVSASTLARA GFLYTGEGDT
VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYFEN SAAQSTNPGV QNGQYKGENY
LGNRNHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM CSEEARLKSF QNWPDYAHLT
PRELASAGLY YTGIDDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNVNIRSE
SDVVSSDRNF PNSTNPPRNP AMADYEARII SFGTWIYSVN KEQLARAGFY ALGEGDKVKC
FHCGGGLTDW KPNEDPWEQH AKWYPGCKYL LEEKGQEYIN NIHLTHSLEE SLARTAENTP
SQTKRIDDTI FQSPMVQEAI RMGFSFREIK KIMEEKVQMC GSNYKSLEVL VADLVNAQKS
STQDESSQTS LQKEVSTEEQ LRRLQEEKLC KICMDRNIAV VFIPCGHLVT CKQCAEAVDK
CPMCYTVITF KQKIFMS
//
