ID B7P2H8_IXOSC Unreviewed; 162 AA.
AC B7P2H8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=G-protein coupled receptor, putative {ECO:0000313|EMBL:EEC00800.1, ECO:0000313|EnsemblMetazoa:ISCW000432-PA};
DE EC=2.7.10.2 {ECO:0000313|EMBL:EEC00800.1};
GN ORFNames=IscW_ISCW000432 {ECO:0000313|EMBL:EEC00800.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00800.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00800.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000432-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000432-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663}.
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DR EMBL; ABJB010472409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010570396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010806828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS622494; EEC00800.1; -; Genomic_DNA.
DR RefSeq; XP_002402367.1; XM_002402323.1.
DR AlphaFoldDB; B7P2H8; -.
DR STRING; 6945.B7P2H8; -.
DR PaxDb; 6945-B7P2H8; -.
DR EnsemblMetazoa; ISCW000432-RA; ISCW000432-PA; ISCW000432.
DR KEGG; isc:IscW_ISCW000432; -.
DR VEuPathDB; VectorBase:ISCI000432; -.
DR VEuPathDB; VectorBase:ISCP_002931; -.
DR VEuPathDB; VectorBase:ISCW000432; -.
DR HOGENOM; CLU_140585_0_0_1; -.
DR InParanoid; B7P2H8; -.
DR OMA; RYAMNIP; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24241:SF188; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EEC00800.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC00800.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..63
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 162 AA; 17750 MW; 789F154BFF944A25 CRC64;
MLATVVLMFA VCWLPIHLMN LILYFDRDAI SPDTDEQEYL YIAAFFSCHW FSMANSFVNP
IIYCFMSDNF RVDLRQLALG CCPTLAAKAG RALNKRSSYG GGSLRSSTVI VSSAGGGASS
LHQNHQRCNG FSSVKSPTSV VALKTLGSCV VDQTPVRFSV YE
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