ID B7P2S3_IXOSC Unreviewed; 1452 AA.
AC B7P2S3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=PKD domain-containing protein {ECO:0000259|PROSITE:PS50093};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW000316 {ECO:0000313|EMBL:EEC00895.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC00895.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC00895.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000316-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000316-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ABJB010060919; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010078772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010092442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010172678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010176416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010198430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010215028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010267895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010313938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011008713; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS624465; EEC00895.1; -; Genomic_DNA.
DR RefSeq; XP_002402963.1; XM_002402919.1.
DR STRING; 6945.B7P2S3; -.
DR PaxDb; 6945-B7P2S3; -.
DR EnsemblMetazoa; ISCW000316-RA; ISCW000316-PA; ISCW000316.
DR KEGG; isc:IscW_ISCW000316; -.
DR VEuPathDB; VectorBase:ISCI000316; -.
DR VEuPathDB; VectorBase:ISCP_018328; -.
DR VEuPathDB; VectorBase:ISCW000316; -.
DR HOGENOM; CLU_251257_0_0_1; -.
DR InParanoid; B7P2S3; -.
DR OMA; ALEWSTI; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IEA:GOC.
DR CDD; cd00146; PKD; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46730:SF1; PLAT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR Pfam; PF00801; PKD; 2.
DR Pfam; PF02010; REJ; 1.
DR SMART; SM00089; PKD; 3.
DR SUPFAM; SSF49299; PKD domain; 3.
DR PROSITE; PS50093; PKD; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1452
FT /note="PKD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010825750"
FT DOMAIN 526..594
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 638..691
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT NON_TER 1452
FT /evidence="ECO:0000313|EMBL:EEC00895.1"
SQ SEQUENCE 1452 AA; 162153 MW; 89C1C01381582C5D CRC64;
MGYSTLVRGW HTFIRVVLFW MVLLEPVIER GWALKNGDCL RADSAPYFQL NPGGYDPAKG
MDGGRCQALC ASISAPYSGV QSKKYCLCSD DPFAERLTAT KKDVCDKGEE MSTLFFHSDL
FSPVEGLRVM PSSSVVNVGE EVAFHLAVKS GKNATVAFNF GDGLPGTKGT LSTEPRYIYW
KPGTYSIVVQ ATPVGASDIV GEQVPQFPTD DVVIDEDDSA DSAVLPYARA VQSGQLEVVQ
GYGSVPGKLD LLLFTVKAET MVVVTTAPEE DTVSWTCPAL VEPGTRFTCH LSVAAGADMT
VDVDPGDGSK RHNMKLLRPT CQGCTFLGNN VTCLEGNSLC SQEANCLRND QCPKRNVYSI
YKMMETVSVM VNKGYFIQRL ATPLQVVSGE FNAATFRKAR DILGFTTSGG RLAYRRTLEG
ESSDLIKRNQ MKGQAVRTDD LLSVDRRFLL SALVYAPVNL TYDYLYTDPG AYEFRLSLQN
KHHDSNVRKM TDVSSQEKLT SFRLEVSRNQ VPTGTEVEIT ARMFGGSDVT MVWNFGDGHT
TKEVVKSVLA GQRFVKQHIF KDPGTYVVQV NSSNLHGNFV ARRSVAVQRP VTEAWELYTN
SPVILPEAVY VTLTYPKTEK LPTDAVARIS FGDRQKAKWK VPSESAEKVS QKFSHVYLKP
GHYNVAINIS NLISSYVLNA KVETATRTTG LLAKVQFQPS DIAPLRVGLG ATNDIFPTTR
PVVFTVKTGT GIVEQFIIET AKGQLLANGT GKQLKYTLNF PEPGQHDVFV YAWNHVQQRT
EPFLVSFRSM EPIEGLDVYM NETTPKDEHI RNFLVSFGLV GTDTCLMVDY GDETPKRAYG
SRSQCFTRYR PDQFQHEGEL ENPMWLQNIY ERGFDYVFSL IAFNDISEQS TSFNITVNNE
PCKPPVIKIR NQVLDPVNAT VFYRLRPVEL YTFTSVECNI SIDVTRAWEA FLLNETGDII
RQVDLTPLDS RTKSMIFVPE FFLDAGMYKL RYNVNMSAPR AKPPMFHKRF AETYIEMKPS
PLLPQMSNGA QSRVTRGFPQ TLILNPGNYS INPDDPTDKN FTVTWFCRRV PYETINRTIA
DEEQNVTAPL YHRLDQLHNI TAQGHDFDTV GFLAAEGMED KGGCFGTGPG LVNISGGALE
WSTIVFYKPN VTYEILAKLE KPDRPPSWGA IQLVLMEKVP PSISVQCQTE KLCYPNDPIG
QKINPVRVGL IGLCIENCDG EMVYSWEVFG SDNLTEVYLE DARDYLVGAT EQKMALSDDF
FKVYYPTFGD FVARLTVTNQ WGVSGVSDLF LHINKPPENG QCSFEPNEGR ALMDKFKASC
SDWTDPEGLD IEFFAFWDVI VQHHRTYLPT RQEFERYLGE RSLDNADAAG DQARMNQMSQ
AIASLMNVRL PDEMENEINY SVRDMATGAL TFLTYGPDSE VTLLLPHGEF QVGADVKDKE
GATTRVNMTT LA
//
