ID B7P3S2_IXOSC Unreviewed; 608 AA.
AC B7P3S2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Organic anion transporter, putative {ECO:0000313|EMBL:EEC01244.1, ECO:0000313|EnsemblMetazoa:ISCW000595-PA};
GN ORFNames=IscW_ISCW000595 {ECO:0000313|EMBL:EEC01244.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC01244.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC01244.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000595-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000595-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657}.
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DR EMBL; ABJB010164880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010377216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010949383; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010962336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011032651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS630446; EEC01244.1; -; Genomic_DNA.
DR RefSeq; XP_002404593.1; XM_002404549.1.
DR AlphaFoldDB; B7P3S2; -.
DR PaxDb; 6945-B7P3S2; -.
DR EnsemblMetazoa; ISCW000595-RA; ISCW000595-PA; ISCW000595.
DR KEGG; isc:IscW_ISCW000595; -.
DR VEuPathDB; VectorBase:ISCI000595; -.
DR VEuPathDB; VectorBase:ISCP_019442; -.
DR VEuPathDB; VectorBase:ISCP_036377; -.
DR VEuPathDB; VectorBase:ISCW000595; -.
DR HOGENOM; CLU_008954_1_2_1; -.
DR InParanoid; B7P3S2; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015347; F:sodium-independent organic anion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0043252; P:sodium-independent organic anion transport; IBA:GO_Central.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF100; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 2.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 541..563
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 403..455
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
SQ SEQUENCE 608 AA; 66838 MW; 0D765CE539384536 CRC64;
MASIWNLSDL RVESGQSSSN LSSCGHYQEV CEPPADVAPL PEPRRKISLT QLPYISRPQS
EQDLLCGWCG FRPNFLINFR HPGYVLFVLC CMVFLQGLVA NGLVYMVLPT IERRFQFRSL
ETGTIVSMYH LASCISAPVM TLVAAKRSKP LYLSLAAVVI AIGTLILTLP HFLVPQYRQS
TYEVDLCPHK GDDPAVCSTP TGNLRSYRFV FWAGHLIVGA GSSPMYTLAL TYLDENLPTT
LSIKYIGQMW AKLEKKSKAA SRKTKAKNAP AMGLRNFPSN LSTLLHNNTF VFLCLAGTSE
TMIMTGMATF MTKFFEAQLG MSSPNIAHIL GCVAMPSACG GILLGGYCVY KLNLGIDGIL
RMCLLCSIVP WFTSFILLYS CPNPKFFGLN HTSSRFFVST VTNQFEQDCN AYCFCPVEFY
NPVCGKDNAT YYSPCFAGCK RDYVYDSLKA YTDCSCIMHG GESFEVGMGA PVTVQADRKK
CALECNALGL YLTGISLYMF FTFLLYTPGV SATISCVLWN SVCDQIGACA VHDNGVMSRN
LFTVVLVLKT VSVLLFLNAL ICLKTGDSER HSHGEDSPDG ETSSVNATHS VQSLHKMGVY
HASSVSLY
//
