ID B7P5M7_IXOSC Unreviewed; 1198 AA.
AC B7P5M7;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Transformation/transcription domain-associated protein, putative {ECO:0000313|EMBL:EEC01899.1, ECO:0000313|EnsemblMetazoa:ISCW001767-PA};
DE EC=2.7.11.1 {ECO:0000313|EMBL:EEC01899.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW001767 {ECO:0000313|EMBL:EEC01899.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC01899.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC01899.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW001767-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW001767-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
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DR EMBL; ABJB010042335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010103731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010137401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010200452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010306596; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010721245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010734619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010740549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010768232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011084211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS642055; EEC01899.1; -; Genomic_DNA.
DR RefSeq; XP_002407745.1; XM_002407701.1.
DR AlphaFoldDB; B7P5M7; -.
DR STRING; 6945.B7P5M7; -.
DR PaxDb; 6945-B7P5M7; -.
DR EnsemblMetazoa; ISCW001767-RA; ISCW001767-PA; ISCW001767.
DR KEGG; isc:IscW_ISCW001767; -.
DR VEuPathDB; VectorBase:ISCI001767; -.
DR VEuPathDB; VectorBase:ISCP_000311; -.
DR VEuPathDB; VectorBase:ISCW001767; -.
DR HOGENOM; CLU_000129_2_0_1; -.
DR InParanoid; B7P5M7; -.
DR OMA; NACATTN; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20206; Tra1_ring; 2.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P5M7};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC01899.1}.
FT DOMAIN 842..1165
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1166..1198
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 576..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC01899.1"
SQ SEQUENCE 1198 AA; 134013 MW; CBFE0963453DAB67 CRC64;
DTSVTVAVGT ELLILSLDLV KNRVGVMGQE MRKAFIGTIL VGLIEKSPDV KVLKAITKMV
EDWVKSKSPF AVNQSPTLRE KSILLVKMMQ FIEKRFPDDL ELNAQFLELV NYVYRDEALK
GTELTSKLEP AFMAGLRCVQ PSIRAKFFEV WEVLHTAVAH APLRSAQPGA LLPAATAGLL
QADALDRDTL ALATPLKEEP PDTEEEIEIE LGEEAPVRGV LENSFRAGSD PRQQLQQLVQ
RQARFLESLR EVRTGGFLAA TAQLCHLDTA LAQHLWVELL PRLWKVLSDK QQSVLAGEIV
PFLCSGSHVV QKDCHPNAIG TFVEALSQCT PPVPIKPALV KELLSHEELL SPRCSKELNQ
WDLLLDYGSS KNCANPHLVL ESAWRAAQQI MELQEAAQIH QGLLPANAGR NTSLYDMRAS
IHTIPSVPIV DCFQKIRQQV KCYLQMSNMM GKNELQEGLD VIESTNLKYF TKDMTAEFYA
LKGLFLSQMG RSEEANKALS AAVQMHDTLV KAWALWGDYL ETLFARDRWE ARQLPLGVSA
LTCFLHACRH QNEPKARKYL AKDKLWIYRR LFSGADKSSS EWGPEQGKPG SAHGSGQGAQ
SGEAPSPNTG QGGATGEGAS QGGQPGGESG PIRATPSMWR CSKIMHMQRD LHPTVLSSLE
GIVDQMVWFR ENWYEEVLRQ LRQGLAKCHA VAFENRGAVS EATVTPHTLN FLKKLVSTFG
VGIENVSSVS TTFSNAASES LARRAQATAQ DPVFQKMKGQ FTTDFDFSVP GAMKLHNLIN
KLKKWIKILE AKTKLLPKSL LIEEKCRFLS NFSQQTAEQP VAIDPFCCPQ NNHYYVRIAR
FMPRVEIVQK HNTAARRLYI RGQNGKIYPY LVVNDACLSD ARREERVLQL LRMLNHHLDK
QKETARRFLN FAVPRVVAVS PQMRLVEDNP ASVSLLHVYK QRCHKRGVEH DSPLGRYYER
LAAVQARGSQ ASHQVLRDIL KDVQGSMVPR HMLRDWAQAA FQQPTHYWTF RKQFTLQLSL
AGFAEFVMHL TRLNPDMMYL HQDSGLMNLS YFKFDVDDIT GDLDANRPVP FRLTPNISEF
ITSIGVTGPM TASMIAIARC VAQPNFKVQA LLRAVLRDEM IAWHKKKQDD AVAPGSAPQD
MEGELLIGMV SKAVSAVMTR LQNLATFDGV DSKVSTLVAA ANSHDNLCRM DPAWHPWL
//
