ID B7P6I4_IXOSC Unreviewed; 393 AA.
AC B7P6I4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Snf2 histone linker PHD ring helicase, putative {ECO:0000313|EMBL:EEC02206.1, ECO:0000313|EnsemblMetazoa:ISCW000059-PA};
DE EC=2.7.11.1 {ECO:0000313|EMBL:EEC02206.1};
GN ORFNames=IscW_ISCW000059 {ECO:0000313|EMBL:EEC02206.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02206.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02206.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000059-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000059-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010765337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011000396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011038338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011048582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS646107; EEC02206.1; -; Genomic_DNA.
DR RefSeq; XP_002408840.1; XM_002408796.1.
DR AlphaFoldDB; B7P6I4; -.
DR STRING; 6945.B7P6I4; -.
DR PaxDb; 6945-B7P6I4; -.
DR EnsemblMetazoa; ISCW000059-RA; ISCW000059-PA; ISCW000059.
DR KEGG; isc:IscW_ISCW000059; -.
DR VEuPathDB; VectorBase:ISCI000059; -.
DR VEuPathDB; VectorBase:ISCP_027887; -.
DR VEuPathDB; VectorBase:ISCW000059; -.
DR HOGENOM; CLU_702623_0_0_1; -.
DR InParanoid; B7P6I4; -.
DR OMA; SAHEDIF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR CDD; cd16569; RING-HC_SHPRH-like; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048695; SHPRH_helical_2nd.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR45865:SF1; E3 UBIQUITIN-PROTEIN LIGASE SHPRH; 1.
DR PANTHER; PTHR45865; E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21324; SHPRH_helical-2nd; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EEC02206.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transferase {ECO:0000313|EMBL:EEC02206.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 201..247
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 282..393
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 393 AA; 43670 MW; DBD1D9E5F2044F60 CRC64;
MWLVSKVNTD LETQKSAVAP SFSGHVTGLQ YIIETQLMQL HSAREALLHT VGDLSAEPST
EEVTAAVECH LRPSRKKRDK CKYCTIHEMF NRYESRLFCF TEGAAHVEEQ NKEDALLASL
RRGNWGDSNL EKIIKSLCKN AAFSDGTIYL HLQVPEQQSR LLVERELHRN DLRKKLGQLF
YLQNLEKAGG SGNASSNPEP CPICQNPLGE RWSVMQCGHN FCIGCIQMML RTPACTRGGG
LLCAVCRSIS AHEDIFFVDV KASKQDAPEF PVKGSHSTKT EGIVRTLLKI KAEDPSAKAL
VFSTWLVVLD VLRKALEDND ISYILLKSAN NSKNNLALFK HDPEVSVLML PLSLGAKGLN
LTEATHVLLI EPILNTADEL QAIGRVHRIG QTK
//
