ID B7P6T2_IXOSC Unreviewed; 702 AA.
AC B7P6T2;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Guanine nucleotide exchange factor for ras-like small gtpase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW000205 {ECO:0000313|EMBL:EEC02304.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02304.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02304.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW000205-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW000205-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010727993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010784179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010930900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011067020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS647752; EEC02304.1; -; Genomic_DNA.
DR RefSeq; XP_002409194.1; XM_002409150.1.
DR AlphaFoldDB; B7P6T2; -.
DR STRING; 6945.B7P6T2; -.
DR PaxDb; 6945-B7P6T2; -.
DR EnsemblMetazoa; ISCW000205-RA; ISCW000205-PA; ISCW000205.
DR KEGG; isc:IscW_ISCW000205; -.
DR VEuPathDB; VectorBase:ISCI000205; -.
DR VEuPathDB; VectorBase:ISCP_024822; -.
DR VEuPathDB; VectorBase:ISCW000205; -.
DR HOGENOM; CLU_015281_0_0_1; -.
DR InParanoid; B7P6T2; -.
DR OMA; VLVWWQY; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF8; RAS-GEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 28..127
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 422..658
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 204..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC02304.1"
SQ SEQUENCE 702 AA; 77494 MW; 84E73ABF03AA7F46 CRC64;
VETSPEDLKK ALEWELGLDS RDMRSHAWYH GTIPRQRAEE LMTADGGFLV RDCVSRPGDY
VLTCCWKGAP LHFVINKVVL QPYTVYERIQ YQFEDDCFDT VPDLVTFYVG NKRPISAASG
AVVSRPYVVT RCKFGHRWIN LTDHLFSLEE TKMLLHAHCA CVCTVFCTGV EPPCNKRLST
LQQLPPEPQL PQKMHHPFVA GLPPHSPHTP AFGTLRGVQG SNPGSNSHQR RGFIRVGSDP
MLSPTMERRP WDHHRPLSST ASSEGASANA DAEDRPPPKP SRVPSRRLQQ RPTGTLGRAS
RSHDQPTAAQ YVNNSEGQGH VYSELAENGI STHADAREPH SPSEVKKKVA TPHRTPRGRV
CATVAARCSD PGKIDRVVTV PEADPVSTFA PDAFATTLLP SDNKPLEKSA MERVRGVLLE
GGPRVLAHHL TRVDLDLLLA EKDRGLGVMS GLELLTLPQG SRLRKDLLER TECLKLFVAA
TVLTCADEAE RVELLNKWIQ VAGDTKTALG NLYGFTGIML GLAMPQISRL KTTWLTLRQR
HTETALAYET KLRPALKHMQ ECSNPQAPNT CLPYLLSLLL ILEHDFGDLG CAQSRRGSDA
SSLELFPWEQ STADYGLLLL VSHLEQGRSL AQQLPTLRRN GQIVLEGIKT DDIALDVFRT
ELHLLFLWGA KGAAVAAGER HSKLGQVLGV MSVRCEPTGT PV
//
