ID B7P8C3_IXOSC Unreviewed; 670 AA.
AC B7P8C3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=polyribonucleotide nucleotidyltransferase {ECO:0000256|ARBA:ARBA00012416};
DE EC=2.7.7.8 {ECO:0000256|ARBA:ARBA00012416};
DE AltName: Full=Polynucleotide phosphorylase 1 {ECO:0000256|ARBA:ARBA00031451};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW016742 {ECO:0000313|EMBL:EEC02845.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC02845.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC02845.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW016742-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW016742-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the polyribonucleotide nucleotidyltransferase
CC family. {ECO:0000256|ARBA:ARBA00007404}.
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DR EMBL; ABJB010186433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS656447; EEC02845.1; -; Genomic_DNA.
DR RefSeq; XP_002401660.1; XM_002401616.1.
DR AlphaFoldDB; B7P8C3; -.
DR STRING; 6945.B7P8C3; -.
DR PaxDb; 6945-B7P8C3; -.
DR EnsemblMetazoa; ISCW016742-RA; ISCW016742-PA; ISCW016742.
DR KEGG; isc:IscW_ISCW016742; -.
DR VEuPathDB; VectorBase:ISCI009086; -.
DR VEuPathDB; VectorBase:ISCP_007180; -.
DR VEuPathDB; VectorBase:ISCW016742; -.
DR HOGENOM; CLU_004217_2_2_1; -.
DR InParanoid; B7P8C3; -.
DR OMA; PISCESH; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0004654; F:polyribonucleotide nucleotidyltransferase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IBA:GO_Central.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd02393; KH-I_PNPase; 1.
DR CDD; cd11363; RNase_PH_PNPase_1; 1.
DR CDD; cd11364; RNase_PH_PNPase_2; 1.
DR Gene3D; 3.30.230.70; GHMP Kinase, N-terminal domain; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_01595; PNPase; 1.
DR InterPro; IPR001247; ExoRNase_PH_dom1.
DR InterPro; IPR015847; ExoRNase_PH_dom2.
DR InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR012162; PNPase.
DR InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR InterPro; IPR015848; PNPase_PH_RNA-bd_bac/org-type.
DR InterPro; IPR036456; PNPase_PH_RNA-bd_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR03591; polynuc_phos; 1.
DR PANTHER; PTHR11252; POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE; 1.
DR PANTHER; PTHR11252:SF0; POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL; 1.
DR Pfam; PF00013; KH_1; 1.
DR Pfam; PF03726; PNPase; 1.
DR Pfam; PF01138; RNase_PH; 2.
DR Pfam; PF03725; RNase_PH_C; 1.
DR Pfam; PF00575; S1; 1.
DR PIRSF; PIRSF005499; PNPase; 1.
DR SMART; SM00322; KH; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF46915; Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3; 1.
DR SUPFAM; SSF55666; Ribonuclease PH domain 2-like; 2.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 2.
DR PROSITE; PS50084; KH_TYPE_1; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:EEC02845.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00117};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EEC02845.1}.
FT DOMAIN 612..670
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC02845.1"
FT NON_TER 670
FT /evidence="ECO:0000313|EMBL:EEC02845.1"
SQ SEQUENCE 670 AA; 73320 MW; 9767725EEE370FFA CRC64;
DGKVLELSTG KIARQADGAV TVKMGNSVLL CTAVVAKKAK EGIGFFPLTI NYREMAYAAG
KIPGGFFKRE GKASDREVLV SRLIDRPIRP LFHPAFVNET HVTCSVLSYD PETPVDILAI
IGASAALSLS PAPYLEIVAA SKVGLINGEF VLNPALELLK TSQLDLVVAG TSDSVMMVES
EAHLLSEEQM LEAVKFGFES FQPVIKIIKE LAEEAKKPKL EMQDLYPASL KKEIEKLFVK
EIKQVFVIKS KQERSTNLDL IPEKVLTHFV SDIENKKYSN YQIESALKSI ESDILRNEIL
EKNRRIDGRS TTDIRQIACE IGLLPSAHGS ALFTRGETQS LVSTTFGTSL DEQIVDSLEG
EYKERFMLNY IFPPYSVNEV MPMKAPSRRE VGHGKLAWRA INPILPNKVQ FPYSIRVVAE
TTESNGSSSM ATVCSSSLAL MYAGVPIKAP VAGIAMGLIK EGKKFAVLSD ILGDEDYFGD
MDFKVAGTSE GITALQMDIK ISGVDFKIMK VALEQARLGR LHILEQMNKV ISKPNSELSK
NAPSTTTIKI DKDKIRDIIG PGGKVIKEIC ETSGAKIDIS DDGSVSVYAS DRDKLKVALD
KIKAIAVEPE IGEIFNGTVM KVLDSGAFIN YLGNKDGFVH ISEISEERIE TVSSVLKQGD
IVKVKLIGFD
//
