ID B7P8V1_IXOSC Unreviewed; 580 AA.
AC B7P8V1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Muscarinic acetylcholine receptor, putative {ECO:0000313|EMBL:EEC03023.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:EEC03023.1};
GN Name=8026302 {ECO:0000313|EnsemblMetazoa:ISCW001961-PA};
GN ORFNames=IscW_ISCW001961 {ECO:0000313|EMBL:EEC03023.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03023.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03023.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW001961-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW001961-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|ARBA:ARBA00010663, ECO:0000256|RuleBase:RU000688}.
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DR EMBL; ABJB010517326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS660344; EEC03023.1; -; Genomic_DNA.
DR RefSeq; XP_002403135.1; XM_002403091.1.
DR AlphaFoldDB; B7P8V1; -.
DR STRING; 6945.B7P8V1; -.
DR PaxDb; 6945-B7P8V1; -.
DR EnsemblMetazoa; ISCW001961-RA; ISCW001961-PA; ISCW001961.
DR GeneID; 8026302; -.
DR KEGG; isc:IscW_ISCW001961; -.
DR VEuPathDB; VectorBase:ISCI001961; -.
DR VEuPathDB; VectorBase:ISCP_020640; -.
DR VEuPathDB; VectorBase:ISCW001961; -.
DR HOGENOM; CLU_009579_11_2_1; -.
DR InParanoid; B7P8V1; -.
DR OMA; YDTPKYF; -.
DR OrthoDB; 4136179at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0016907; F:G protein-coupled acetylcholine receptor activity; IBA:GO_Central.
DR GO; GO:0004993; F:G protein-coupled serotonin receptor activity; IBA:GO_Central.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007197; P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IBA:GO_Central.
DR CDD; cd15301; 7tmA_mAChR_DM1-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000995; Musac_Ach_rcpt.
DR PANTHER; PTHR24247; 5-HYDROXYTRYPTAMINE RECEPTOR; 1.
DR PANTHER; PTHR24247:SF268; MUSCARINIC ACETYLCHOLINE RECEPTOR DM1; 1.
DR Pfam; PF00001; 7tm_1; 2.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00243; MUSCARINICR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transferase {ECO:0000313|EMBL:EEC03023.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..548
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 245..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 65174 MW; 03CBBBEA37344B58 CRC64;
MALLGAAFNA SAASTDAGPL DDVTINITNT SLTESGGTSS PYSLPEVILI AILAALLSTL
TIIGNLMVMI SFKLDKQLQT ISNYFLLSLA IADFSIGVIS MPLFTMYTLY DHWPLGTFIC
DTWLAFDYLT SNASVLNLLI ISFDRYFSVT RPLTYRARRT TKRAAIMIAS AWVISLVLWP
PWIYSWPYIE GRRSVPVDRC YIQFLETNIY VTFGTALAAF YVPVTVMCIL YWRIWRETEK
RQKDLTQLQA GKKDGSRKST SSDDPAESED FRRGRSDSCA PDVETTYVPT SLCVETSKYL
PPAVPKRRRL KDVLLSWCRI DNDKEDDDST SHGGSPGTQT PASVETPVQS ASMTFRADQL
VQLNPAGRQV SIPMTDRNGL RRSDRPSTSR SYSSDSVYTI LIRLPTQPSL EGGASQASIK
MILEEDAEKN ETTTTFARTS SEDSTTLRTA EAGIDTIRIP LNTKLVHRQV AKQKAPKKKR
KQQERKQEKK AAKTLSAILL AFIVTWTPYN VLVLIKTVSS CDDCIPTGLW NFVYYLCYIN
STVNPLCYAL CNANFRRTYM RILSCKWHNK QRSMNRGYFS
//
