ID B7P950_IXOSC Unreviewed; 207 AA.
AC B7P950;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=DNA-binding protein, putative {ECO:0000313|EMBL:EEC03122.1, ECO:0000313|EnsemblMetazoa:ISCW017350-PA};
DE EC=1.3.1.74 {ECO:0000313|EMBL:EEC03122.1};
GN ORFNames=IscW_ISCW017350 {ECO:0000313|EMBL:EEC03122.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03122.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03122.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW017350-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW017350-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the HMGB family.
CC {ECO:0000256|ARBA:ARBA00008774}.
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DR EMBL; ABJB010973418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS661587; EEC03122.1; -; Genomic_DNA.
DR RefSeq; XP_002403591.1; XM_002403547.1.
DR AlphaFoldDB; B7P950; -.
DR STRING; 6945.B7P950; -.
DR PaxDb; 6945-B7P950; -.
DR EnsemblMetazoa; ISCW017350-RA; ISCW017350-PA; ISCW017350.
DR KEGG; isc:IscW_ISCW017350; -.
DR VEuPathDB; VectorBase:ISCI017350; -.
DR VEuPathDB; VectorBase:ISCP_010765; -.
DR VEuPathDB; VectorBase:ISCW017350; -.
DR HOGENOM; CLU_082854_0_0_1; -.
DR InParanoid; B7P950; -.
DR OMA; PHSANEV; -.
DR OrthoDB; 1222485at2759; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032440; F:2-alkenal reductase [NAD(P)+] activity; IEA:UniProtKB-EC.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd21978; HMG-box_HMGB_rpt1; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017967; HMG_boxA_CS.
DR PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR PANTHER; PTHR48112:SF32; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; HMG-box; 2.
DR PROSITE; PS00353; HMG_BOX_1; 1.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 1: Evidence at protein level;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267,
KW ECO:0000313|EMBL:EEC03122.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Oxidoreductase {ECO:0000313|EMBL:EEC03122.1};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P950};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 7..77
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 96..164
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 7..77
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 96..164
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 50..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 111..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..207
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 24127 MW; 431EB7508D05029E CRC64;
MGKGDKPRGR MSAYAFFVQT CREEHKKKHP SENVVFAEFS KKCAERWKTM SEGEKKRFHQ
MADKDKKRFD SEMADYKPPK GEKSKKRKRT KDPNAPKRPL SAFFWFCNDE RPNVRQESPD
ASVGEVAKEL GRRWNDVGDD TKSKYEGLAA KDKARYEKEL KAYKNKKTKG ASPPKEKGKK
KDEDEDDDDD AEEEEEEAEE EDDEDDE
//
