ID B7P9Z3_IXOSC Unreviewed; 1311 AA.
AC B7P9Z3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=phosphoribosylformylglycinamidine synthase {ECO:0000256|ARBA:ARBA00012747};
DE EC=6.3.5.3 {ECO:0000256|ARBA:ARBA00012747};
DE AltName: Full=Formylglycinamide ribonucleotide amidotransferase {ECO:0000256|ARBA:ARBA00032632};
DE AltName: Full=Formylglycinamide ribotide amidotransferase {ECO:0000256|ARBA:ARBA00029823};
GN ORFNames=IscW_ISCW017327 {ECO:0000313|EMBL:EEC03415.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC03415.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC03415.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW017327-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW017327-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC phospho-D-ribosyl)glycinamide: step 1/2.
CC {ECO:0000256|ARBA:ARBA00004920}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the FGAMS family.
CC {ECO:0000256|ARBA:ARBA00008608}.
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DR EMBL; ABJB010076760; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010184351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010214710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010259843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010299186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010393928; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010441573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010959309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011058283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS668046; EEC03415.1; -; Genomic_DNA.
DR RefSeq; XP_002405859.1; XM_002405815.1.
DR STRING; 6945.B7P9Z3; -.
DR PaxDb; 6945-B7P9Z3; -.
DR EnsemblMetazoa; ISCW017327-RA; ISCW017327-PA; ISCW017327.
DR KEGG; isc:IscW_ISCW017327; -.
DR VEuPathDB; VectorBase:ISCI017327; -.
DR VEuPathDB; VectorBase:ISCP_006087; -.
DR VEuPathDB; VectorBase:ISCW017327; -.
DR HOGENOM; CLU_001031_0_0_1; -.
DR InParanoid; B7P9Z3; -.
DR OMA; LSANWMW; -.
DR UniPathway; UPA00074; UER00128.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IBA:GO_Central.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006164; P:purine nucleotide biosynthetic process; IBA:GO_Central.
DR CDD; cd01740; GATase1_FGAR_AT; 1.
DR CDD; cd02203; PurL_repeat1; 1.
DR CDD; cd02204; PurL_repeat2; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 1.10.8.750; Phosphoribosylformylglycinamidine synthase, linker domain; 1.
DR Gene3D; 3.90.650.10; PurM-like C-terminal domain; 2.
DR Gene3D; 3.30.1330.10; PurM-like, N-terminal domain; 2.
DR HAMAP; MF_00419; PurL_1; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR040707; FGAR-AT_N.
DR InterPro; IPR010073; PurL_large.
DR InterPro; IPR041609; PurL_linker.
DR InterPro; IPR010918; PurM-like_C_dom.
DR InterPro; IPR036676; PurM-like_C_sf.
DR InterPro; IPR036921; PurM-like_N_sf.
DR InterPro; IPR036604; PurS-like_sf.
DR NCBIfam; TIGR01735; FGAM_synt; 1.
DR PANTHER; PTHR10099; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR PANTHER; PTHR10099:SF1; PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE; 1.
DR Pfam; PF02769; AIRS_C; 2.
DR Pfam; PF18072; FGAR-AT_linker; 1.
DR Pfam; PF18076; FGAR-AT_N; 1.
DR Pfam; PF13507; GATase_5; 1.
DR SMART; SM01211; GATase_5; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR SUPFAM; SSF109736; FGAM synthase PurL, linker domain; 1.
DR SUPFAM; SSF56042; PurM C-terminal domain-like; 2.
DR SUPFAM; SSF55326; PurM N-terminal domain-like; 2.
DR SUPFAM; SSF82697; PurS-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962,
KW ECO:0000256|PROSITE-ProRule:PRU00605};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:EEC03415.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7P9Z3};
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 39..156
FT /note="Phosphoribosylformylglycinamidine synthase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF18076"
FT DOMAIN 185..234
FT /note="Phosphoribosylformylglycinamidine synthase linker"
FT /evidence="ECO:0000259|Pfam:PF18072"
FT DOMAIN 446..602
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT DOMAIN 852..971
FT /note="PurM-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02769"
FT ACT_SITE 1144
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1268
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 1270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 1311 AA; 142730 MW; FCB307010EA7721B CRC64;
MAILRFYQSP ALSESAARGK MAAINGALGE EAVASVTTEY CYYVQLCGQE ALDQEQRKRL
VWLLTPGFKV RLAPETGLAE TNGNIVVEIG PRLNFSTPSS TQSVAICQTI GLECVDRVER
STRYLIALKS GHTKLSEAAK RKVVDVLHDR MTEAHYVTPV TSFELPPSTH SWEEVDILTH
GRPALERASA QLGLSFDNWD LDFYTDLFRN KLKRNPTTVE CFDLAQSNSE HSRHWFFKGR
MVVDGKEEPG SLFSLITATQ DTSNDNNVIK FSDNSSAIRG YELRVLQPKD TTVGSAYTVV
DAKRHIIFTA ETHNFPTGVA PFSGATTGTG GRIRDVHAAG RGAHEIAATA GYCFGNLLIP
GYDLPWEESL EYPGNFASPL EVAVEASNGA SDYGNKFGEP VLSGFSRSFG MVVPGGERRE
WIKPIMFSAG IGSIDGDQIT KEKPAKGMLV VKIGGPVYRI GVGGGAASSV TVQGDQEAEL
DFGAVQRGDA EMEQKLHRLV RACIERGARQ NPILSIHDQG AGGNGNVLKE IVEPAGATIW
TERFQLGDPT ISTLELWGAE YQESDAILVH PKDRETLERI AERERCPVAF VGEVTGDGRI
VLKEAGKSGK RDPVDLDLDS VLGDMPRKVF ELSSYKPVLK PLSLPDGLKV QEALQRVLRL
PSVASKRYLT NKARQSLLRI SLDNQVFCEM ALPSSQNLFY ACPLFHVGSA TAIGEQPIKG
LLCPAAGARM SVAEAVSNLV FARISSLQDV KCSGNWMWAA KLPGEGAALY EACKAMCASM
SALGIAVDGG KDSLSMAARV GKDTVKAPGA IVVSTYAPCP DITATVTPDL KMPSARQRGV
LLHIDITPDK RRLGGTALAQ CFKQLGDEVP DLDDPRRLRT AFNTTQELLC EGLLMSGHDV
SDGGLVTCLL EMAFAGNCGL EVDVPSKGDA IAALFHEEVG WVLEVEPRNQ ARVEEAFERA
GVHCVALGHS VGFGPKAQVS VSVAGEPVIS GKVCDLRDVW EETSYQLELR QCDPECAAEE
RQGLLKRTAP PYKLTFSLDI PRRNPEPQLR VAVLREEGVN SDREMAASFF NAGFEAWDVT
MSDLLRGSVT LDQFRGLVFP GGFSYADVLG SARGWAASLL FHEKLAAQLA AFKDRPDTFS
FGICNGCQLM ALLGWSGSVE PGTQLLHNRS GRFECRFTTV RIEPGPAIML AGMEDSVLGV
WVAHGEGRFE FRHDALLDEM ESQRLVGMRY VNDAGAPTIE YPLNPNGSPR GVAALCSRDG
RHLAVMPHPE RCSLPWQWAY VPQEWKRTKF AVSPWAKMYD NAYAWCTGVA Q
//