ID B7PDB4_IXOSC Unreviewed; 614 AA.
AC B7PDB4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=IscW_ISCW003413 {ECO:0000313|EMBL:EEC04586.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC04586.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC04586.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003413-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003413-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010158272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010205947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010236763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010487560; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010543504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010873530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010878902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS689119; EEC04586.1; -; Genomic_DNA.
DR RefSeq; XP_002410714.1; XM_002410669.1.
DR AlphaFoldDB; B7PDB4; -.
DR STRING; 6945.B7PDB4; -.
DR PaxDb; 6945-B7PDB4; -.
DR EnsemblMetazoa; ISCW003413-RA; ISCW003413-PA; ISCW003413.
DR KEGG; isc:IscW_ISCW003413; -.
DR VEuPathDB; VectorBase:ISCI003413; -.
DR VEuPathDB; VectorBase:ISCP_027384; -.
DR VEuPathDB; VectorBase:ISCW003413; -.
DR HOGENOM; CLU_445024_0_0_1; -.
DR InParanoid; B7PDB4; -.
DR OMA; MDASYQI; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd16450; mRING-C3HGC3_RFWD3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037381; RFWD3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR16047:SF7; E3 UBIQUITIN-PROTEIN LIGASE RFWD3; 1.
DR PANTHER; PTHR16047; RFWD3 PROTEIN; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PDB4};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 176..220
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REPEAT 376..417
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 272..299
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 25..44
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 67360 MW; FC9DC298CCA29909 CRC64;
MGSGNNPGQR LPPGPPRSSD AEMSDVDADV DAETETEGSD LEDGLLSDSD ATVSNVSTVS
DAWDGDLDIF LGSDDGSDSN DMHFVETESY SDDEDYDDSG GSSVQVLSEA EQLDVSSVVE
VWTAHDEADA ANITTWKKIS LRSRSGVPLR RSRTPRHLRL RLPWNGAWPK KREWVCTICF
EAWTNSGEHR LVSLKCGHLY GQNCIEKWLK GQPAKCPQCN AAAKKADIRH IYAQKLKVLD
TTELDRVVTE LNVEREKRKR SEVEVVLLNQ KYKLLHCDYE KLKAELMDLK EVQKKMRCEA
PAWLGEGSSR SQSQRSSPGG FTLDRVLHLG SSTSCRNLAT SAILGMLVAS QSQSGLFRGY
GIRKVSLLDF KSSEFILTHQ GEIRDIAFHN SDALVLSASL DKSVKLTSVL TNSIVQTYPQ
PVEAWSCAWD RENSNRFFAG LRNGTVSVYD LRVTSGPVCS LPGTDRYRPV VAMQHVPKGH
PSSEDRWGAR MALIAPREHC GACVCNLSFP ACPDDSSGSF HVVQSFSGGP TQVQLSRSCL
CVDPEDVSNF WVIAGDESYK AVLIWDVASG KRIHQLASDG IVLDLAPLET GGSGWGLAAL
AKSALSLYTW KAPN
//
