ID B7PHG8_IXOSC Unreviewed; 277 AA.
AC B7PHG8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Glutamate carrier protein, putative {ECO:0000313|EMBL:EEC06040.1, ECO:0000313|EnsemblMetazoa:ISCW018293-PA};
GN ORFNames=IscW_ISCW018293 {ECO:0000313|EMBL:EEC06040.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06040.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06040.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018293-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018293-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004448}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; ABJB010926090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS712856; EEC06040.1; -; Genomic_DNA.
DR RefSeq; XP_002402794.1; XM_002402750.1.
DR AlphaFoldDB; B7PHG8; -.
DR STRING; 6945.B7PHG8; -.
DR PaxDb; 6945-B7PHG8; -.
DR EnsemblMetazoa; ISCW018293-RA; ISCW018293-PA; ISCW018293.
DR KEGG; isc:IscW_ISCW018293; -.
DR VEuPathDB; VectorBase:ISCI018293; -.
DR VEuPathDB; VectorBase:ISCP_005276; -.
DR VEuPathDB; VectorBase:ISCW018293; -.
DR HOGENOM; CLU_015166_3_4_1; -.
DR InParanoid; B7PHG8; -.
DR OMA; ILCNEGP; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015183; F:L-aspartate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005313; F:L-glutamate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015810; P:aspartate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015813; P:L-glutamate transmembrane transport; IBA:GO_Central.
DR GO; GO:0043490; P:malate-aspartate shuttle; IBA:GO_Central.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45678:SF5; AT03939P-RELATED; 1.
DR PANTHER; PTHR45678; MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00926; MITOCARRIER.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PHG8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 246..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 1..49
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 57..168
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 177..266
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 277 AA; 30135 MW; EC9504DDC0AB7EE0 CRC64;
MYRSMLDCFR KSYAAEGFFG MYRGSAVNIL LITPEKAIKL AANDWFRHGL SSSAGKLSLT
QEMLAGGGAG FCQIIVTTPM ELLKIQLQDA GRTGRYISIR LHCKFPKVAA RVFRCAGADK
RLSARAVATQ LIRERGLVGL YRGTGATMLR DVTFSVIYFP LFAHLNSLGP RRGDGTSVFW
ASFLAGCGAG SAAAFCVNPC DVVKTRLQLL SRAPGEVSYK GIPDAFYRIL REEGIRAFFK
GAGCRVIVIA PLFGIAQTVY FLGVAEFLLG MDRAKTA
//
