ID B7PHW5_IXOSC Unreviewed; 474 AA.
AC B7PHW5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Fatty acyl-CoA reductase {ECO:0000256|RuleBase:RU363097};
DE EC=1.2.1.84 {ECO:0000256|RuleBase:RU363097};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW003967 {ECO:0000313|EMBL:EEC06187.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06187.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06187.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW003967-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW003967-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
CC {ECO:0000256|RuleBase:RU363097}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain
CC primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84;
CC Evidence={ECO:0000256|RuleBase:RU363097};
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928, ECO:0000256|RuleBase:RU363097}.
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DR EMBL; ABJB010201188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010225825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010497169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010750847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010875261; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011082148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS715201; EEC06187.1; -; Genomic_DNA.
DR RefSeq; XP_002403678.1; XM_002403634.1.
DR AlphaFoldDB; B7PHW5; -.
DR STRING; 6945.B7PHW5; -.
DR PaxDb; 6945-B7PHW5; -.
DR EnsemblMetazoa; ISCW003967-RA; ISCW003967-PA; ISCW003967.
DR KEGG; isc:IscW_ISCW003967; -.
DR VEuPathDB; VectorBase:ISCI003967; -.
DR VEuPathDB; VectorBase:ISCP_013775; -.
DR VEuPathDB; VectorBase:ISCW003967; -.
DR HOGENOM; CLU_024661_0_2_1; -.
DR InParanoid; B7PHW5; -.
DR OMA; RCINWEN; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0102965; F:alcohol-forming long-chain fatty acyl-CoA reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IBA:GO_Central.
DR GO; GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IBA:GO_Central.
DR CDD; cd05236; FAR-N_SDR_e; 1.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11011:SF45; FATTY ACYL-COA REDUCTASE; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF03015; Sterile; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW ECO:0000256|RuleBase:RU363097};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU363097}; NADP {ECO:0000256|RuleBase:RU363097};
KW Oxidoreductase {ECO:0000256|RuleBase:RU363097,
KW ECO:0000313|EMBL:EEC06187.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 27..296
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 368..459
FT /note="Fatty acyl-CoA reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03015"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC06187.1"
SQ SEQUENCE 474 AA; 52563 MW; 022092B4EFFCC2BC CRC64;
FLRAVSVAEE AGYSRVKSFY QDQVIFITGS TGFLGKVLVE KLLRSCPGIE RIYLLIRPKK
GSSPAERLEL LLGSECFKGL RQECPSSLNK LQVVEGNLTD EKMGLKSSDY ECLAAEVSVV
FHSAATIRFN DTLRNAVKIN MEGTKRVLDL CHSTKGMKAF VHVSTAYVNS DDKILEERIY
SPTVEPDHII SLTKTMSEVD LQKRAPELLG AKPNTYVFTK SLAESIVAQH GRGLPLVIVR
PSIVSASWRE PFPGWVEGLH GGNFLVASGV SGVLTTLVGN KNAVLDLVPV DIVASTLIVA
ACQAPPGERE EPAVYNCTSG AINKVLLGEA ARLTTVLARR YPSSLPFGRP GVAVTMSPSY
QAVAVFVFNY LPALIFDLMR QENGKNVRVV DVVTRNKVFL DSVTFFLTRS WNFSADKFLQ
LNEMSTPQDR EIFNTDIRCI NWENYWEDYV KGVRRYLLKL EPAVVPDFAK PTER
//
