ID B7PJX4_IXOSC Unreviewed; 497 AA.
AC B7PJX4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE RecName: Full=Phorbol-ester/DAG-type domain-containing protein {ECO:0000259|PROSITE:PS50081};
GN ORFNames=IscW_ISCW017806 {ECO:0000313|EMBL:EEC06896.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC06896.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC06896.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW017806-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW017806-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010304631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010621852; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010770768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010787389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010831034; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS729014; EEC06896.1; -; Genomic_DNA.
DR RefSeq; XP_002408810.1; XM_002408766.1.
DR AlphaFoldDB; B7PJX4; -.
DR PaxDb; 6945-B7PJX4; -.
DR EnsemblMetazoa; ISCW017806-RA; ISCW017806-PA; ISCW017806.
DR KEGG; isc:IscW_ISCW017806; -.
DR VEuPathDB; VectorBase:ISCI017806; -.
DR VEuPathDB; VectorBase:ISCP_007645; -.
DR VEuPathDB; VectorBase:ISCW017806; -.
DR HOGENOM; CLU_016790_0_0_1; -.
DR InParanoid; B7PJX4; -.
DR OMA; ACHICAR; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20831; C1_dGM13116p-like; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR039934; C2CD2/C2CD2L.
DR InterPro; IPR002219; PE/DAG-bd.
DR PANTHER; PTHR21119:SF5; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR21119; UNCHARACTERIZED; 1.
DR Pfam; PF00130; C1_1; 1.
DR SMART; SM00109; C1; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PJX4};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 422..473
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 232..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 54714 MW; 8CA46B95E6C6F586 CRC64;
MHRYNLLVEK LSGKKPHSVD QRALDDIILE SVVDALSYTV TDLSCSGQKD FPNFKHREPV
SEIIQHTQLD QMNSVPSLAK HDQRLLVKVI KASNLAGTKG ITLDQNSSEV LFELYDKSKP
AGENFLGLGI VGISELRRVP SQRQIITLQS RPLEYDNITG SLTVEFLYME GSQIPVTADS
QMATEFSQQN RIVEKNSRIT SDGRVITTTT IKRSPTTENG SSLTEAALKE LEAKGRSPTA
TKSTLIIHSV QRSDETPLSI SPSSLRKQDH NSVERSASSS CSEAEGEGAS EKPKKRTLLG
KIRKRLSFKK NRSKSVEVRP DAESASRSSS RSVSTDRAKS VPLGRNSHLD VPGARNNGST
RSSISEGSGI SAASSRTFVS DKSLLVVEAK EDGVLRHYLI PPSLAHRSKW RRKGVKLHIY
NDHVFVAKHL PGGTACHICA RLLTRRLGKQ GYMCRGCNLL CHKSCHVKTE TVCKNSSVGT
MQMEPVEDPH PPRMKAS
//
