ID B7PN07_IXOSC Unreviewed; 513 AA.
AC B7PN07;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE SubName: Full=Guanine nucleotide-binding protein, putative {ECO:0000313|EMBL:EEC07979.1, ECO:0000313|EnsemblMetazoa:ISCW018505-PA};
DE EC=2.7.11.7 {ECO:0000313|EMBL:EEC07979.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW018505 {ECO:0000313|EMBL:EEC07979.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC07979.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC07979.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW018505-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW018505-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat PRL1/PRL2 family.
CC {ECO:0000256|ARBA:ARBA00025726}.
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DR EMBL; ABJB010137418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010806068; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS749722; EEC07979.1; -; Genomic_DNA.
DR RefSeq; XP_002435155.1; XM_002435110.1.
DR AlphaFoldDB; B7PN07; -.
DR STRING; 6945.B7PN07; -.
DR PaxDb; 6945-B7PN07; -.
DR EnsemblMetazoa; ISCW018505-RA; ISCW018505-PA; ISCW018505.
DR KEGG; isc:IscW_ISCW018505; -.
DR VEuPathDB; VectorBase:ISCI018505; -.
DR VEuPathDB; VectorBase:ISCP_038048; -.
DR VEuPathDB; VectorBase:ISCW018505; -.
DR HOGENOM; CLU_000288_72_2_1; -.
DR InParanoid; B7PN07; -.
DR OMA; MFSCGLD; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0071013; C:catalytic step 2 spliceosome; IBA:GO_Central.
DR GO; GO:0000974; C:Prp19 complex; IBA:GO_Central.
DR GO; GO:0016905; F:myosin heavy chain kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR045241; Prp46/PLRG1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19923:SF0; PLEIOTROPIC REGULATOR 1; 1.
DR PANTHER; PTHR19923; WD40 REPEAT PROTEINPRL1/PRL2-RELATED; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B7PN07};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000313|EMBL:EEC07979.1};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 199..240
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 241..282
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 283..324
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 325..366
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 408..448
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC07979.1"
SQ SEQUENCE 513 AA; 57379 MW; 65320C162627A45F CRC64;
FTQDVQKHSV HTLVFRSLKR THDMFLSDQA NPPPQDETSE KLKVSVKTKD EYGLVMHLVK
SNPQNYRPNV ERPAHGDDAS VRRRRAAPWG RRLHHCQATP STVAGSLLRS LREGQINAPY
EFVSSNHCTL ARLGCAIRFE LGRDLPRRCD GTDYSGFGTM FGVQMMVLAG QQQLAVAPRK
PVTIPKPQWH PPWKLYRVIS GHTGWVRCLA VEPGNQWFCT GSNDRIIKIW DLASGKLKLS
LTGHISGVRG LAVSPRQPYL FSCGEDKQVK CWDLEYNKVI RHYHGHLSGV YALSLHPTID
VLVTGGRDAT GRVWDMRTKA SIHSLVGHSN TVASVQSQAA EPQVLTGSHD CTIRLWDLVS
GKSRVTLTHH KKSVRALLVH PKLYAFASGG PDNIKQWKCP DGKFIQNLSG HNAIVNCLGM
NDDGVLVSGG DNGTLFFWDW RTGYNFQRLQ APVQPGSIDS EAGIFACLFD MSGSRLITAE
ADKTVKIFRE DDTATEETHP VNWKPDILKR RRF
//
