ID B7PXB4_IXOSC Unreviewed; 207 AA.
AC B7PXB4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 92.
DE SubName: Full=Homeobox protein dbx, putative {ECO:0000313|EMBL:EEC11236.1, ECO:0000313|EnsemblMetazoa:ISCW020093-PA};
DE EC=3.5.4.4 {ECO:0000313|EMBL:EEC11236.1};
GN ORFNames=IscW_ISCW020093 {ECO:0000313|EMBL:EEC11236.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC11236.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC11236.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW020093-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW020093-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the H2.0 homeobox family.
CC {ECO:0000256|ARBA:ARBA00038504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010134700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010160853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010167522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010300333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS813081; EEC11236.1; -; Genomic_DNA.
DR RefSeq; XP_002400053.1; XM_002400009.1.
DR AlphaFoldDB; B7PXB4; -.
DR PaxDb; 6945-B7PXB4; -.
DR EnsemblMetazoa; ISCW020093-RA; ISCW020093-PA; ISCW020093.
DR KEGG; isc:IscW_ISCW020093; -.
DR VEuPathDB; VectorBase:ISCI020093; -.
DR VEuPathDB; VectorBase:ISCP_005769; -.
DR VEuPathDB; VectorBase:ISCW020093; -.
DR HOGENOM; CLU_1327685_0_0_1; -.
DR InParanoid; B7PXB4; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046936; F:2'-deoxyadenosine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24331; DBX; 1.
DR PANTHER; PTHR24331:SF0; DBX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Hydrolase {ECO:0000313|EMBL:EEC11236.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 56..116
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 58..117
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22210 MW; 00299CA142F7B357 CRC64;
MEGLGPGLSG GEQFGLGPGR SQLHGSAGAP GGATGPLGFP LPATFPWAAT ARGKPRRGMM
RRAVFSDAQR QGLEKRFQIQ KYISKPDRKK LAEKLGLKDS QVKIWFQNRR MKWRNSKERE
LLSSGGSREQ TLPTKSNPNP DLSDVSSPSL HPSSTTGNGA SSQGPTSPHQ APTAAASLAE
HLLRASRDED DRQSAGDSDE DVEIKVL
//
