ID B7Q2M5_IXOSC Unreviewed; 436 AA.
AC B7Q2M5;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|Pfam:PF00060};
GN ORFNames=IscW_ISCW020630 {ECO:0000313|EMBL:EEC13097.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC13097.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC13097.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW020630-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW020630-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; ABJB010050201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010188839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010241676; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010319081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011120790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS844967; EEC13097.1; -; Genomic_DNA.
DR RefSeq; XP_002410905.1; XM_002410860.1.
DR AlphaFoldDB; B7Q2M5; -.
DR PaxDb; 6945-B7Q2M5; -.
DR EnsemblMetazoa; ISCW020630-RA; ISCW020630-PA; ISCW020630.
DR KEGG; isc:IscW_ISCW020630; -.
DR VEuPathDB; VectorBase:ISCI020630; -.
DR VEuPathDB; VectorBase:ISCP_038039; -.
DR VEuPathDB; VectorBase:ISCW020630; -.
DR HOGENOM; CLU_628957_0_0_1; -.
DR InParanoid; B7Q2M5; -.
DR OMA; TMSANIF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF40; IONOTROPIC RECEPTOR 40A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 375..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 122..382
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00060"
SQ SEQUENCE 436 AA; 49310 MW; B84908FAD472AB14 CRC64;
MVAYNLWALA RFLHRSGCLA NTAWLSERLT LAAAEDLAAT WTKDPQAHYK LLLADQPLTT
SRRLLLALES DLALSEISFE VNRTKVVSYQ YPAVFDVISF VARAPGVTPF AFAIIRPFDG
QIWLSVALSL LVGSLLLEAL RLSPAESGPG DRPNFWFLLS TLGRQNAWQG EHESPGYRLF
LGPWWLYVLV MTTLYSGRLV AFMSVPVYEP SIRNLEQLED AIKHKGFKLC THRQTIFIEY
IRVAYERKMG DESSLLVSDR RTGLLWALKY PYAYMDSKMS ILSGMSTLLD AKDALRLHVA
DDNMGVEYCG AVFQKDCPLR EQLNAASRVL FETGHLTKWL SQAMRRLDEV TEDPRHDFHQ
RRENPLSASD FNGSFYLLGA GFVVAAAALG LEMCCMALRD RMVVYYRPRT VLKKSGLRPL
GKPRTDRDLK VALAVR
//
