ID B7Q8K1_IXOSC Unreviewed; 411 AA.
AC B7Q8K1;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=Aldehyde dehydrogenase, putative {ECO:0000313|EMBL:EEC15173.1, ECO:0000313|EnsemblMetazoa:ISCW010914-PA};
DE EC=1.5.1.6 {ECO:0000313|EMBL:EEC15173.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW010914 {ECO:0000313|EMBL:EEC15173.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC15173.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC15173.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW010914-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW010914-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010164850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010207493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010208245; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010264833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010313588; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010428092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010827833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010921979; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010939147; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010967253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS884515; EEC15173.1; -; Genomic_DNA.
DR RefSeq; XP_002405185.1; XM_002405141.1.
DR AlphaFoldDB; B7Q8K1; -.
DR STRING; 6945.B7Q8K1; -.
DR PaxDb; 6945-B7Q8K1; -.
DR EnsemblMetazoa; ISCW010914-RA; ISCW010914-PA; ISCW010914.
DR KEGG; isc:IscW_ISCW010914; -.
DR VEuPathDB; VectorBase:ISCI010914; -.
DR VEuPathDB; VectorBase:ISCP_030566; -.
DR VEuPathDB; VectorBase:ISCW010914; -.
DR HOGENOM; CLU_670096_0_0_1; -.
DR InParanoid; B7Q8K1; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0004029; F:aldehyde dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IBA:GO_Central.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF190; 10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:EEC15173.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 184..407
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 49..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC15173.1"
SQ SEQUENCE 411 AA; 45216 MW; 9262D6DE95F471CB CRC64;
TGRLDGPASG GTGDHRVPGL WRRVHARAED THRHVRGDVP LLCRLVRQDP RQHRAREPRP
AQEEPQLHAQ GAHRGLRTHH ALELPTDDGV VEECRLPGGW QHAGPQARPG VPAHGAQAGR
ARRPRGLPTR GLQRAAGLRH CGGPGAVRPP GRAQSGLHGL HRGGPGRDAQ LRRVQHQTLL
PRAGGKVAAH RLRGLRHDMA VRQGMNSVFF NKGENCIAAG RLFVEESIHE QFVERVVSET
KKIVIGDPLD RRTSHGPQNH RRHMEKLLEY VAQGEKEGAR LVYGGRRLDR PGFFLEPTVF
VDVDDHMFVA KEESFGPIML VSKFKDGDVD GVLRRANGTE YGLASGVFTR DLSKALRVSE
GLQAGTCFVN CYNKTDVAAP FGGCKQSGFG KDLGEEALKE YLHVKCVTVE Y
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