ID B7QAV8_IXOSC Unreviewed; 461 AA.
AC B7QAV8;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 72.
DE SubName: Full=Arylsulfatase B, putative {ECO:0000313|EMBL:EEC15980.1, ECO:0000313|EnsemblMetazoa:ISCW012462-PA};
DE EC=3.1.6.12 {ECO:0000313|EMBL:EEC15980.1};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW012462 {ECO:0000313|EMBL:EEC15980.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC15980.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC15980.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW012462-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW012462-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; ABJB010133279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010329428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010459010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010588497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010627820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010771354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010805275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010828859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010980055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB011095326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS896947; EEC15980.1; -; Genomic_DNA.
DR RefSeq; XP_002412684.1; XM_002412639.1.
DR AlphaFoldDB; B7QAV8; -.
DR PaxDb; 6945-B7QAV8; -.
DR EnsemblMetazoa; ISCW012462-RA; ISCW012462-PA; ISCW012462.
DR KEGG; isc:IscW_ISCW012462; -.
DR VEuPathDB; VectorBase:ISCI012462; -.
DR VEuPathDB; VectorBase:ISCP_036714; -.
DR VEuPathDB; VectorBase:ISCW012462; -.
DR HOGENOM; CLU_006332_10_1_1; -.
DR InParanoid; B7QAV8; -.
DR OMA; KHASHIC; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0003943; F:N-acetylgalactosamine-4-sulfatase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 2.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF273; RE14504P; 1.
DR Pfam; PF00884; Sulfatase; 2.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:EEC15980.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 9..74
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT DOMAIN 182..314
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT NON_TER 461
FT /evidence="ECO:0000313|EMBL:EEC15980.1"
SQ SEQUENCE 461 AA; 51378 MW; A95F0E6C750B4465 CRC64;
MTAQASRRPH IVVIVADDLG WGDVSFHGSR QIPTPNIDTL AGDGLALHHY YVQSSGAATR
SALMTGLYPI HTGIKHASHI CISARLIPLS GGIVRCHIVL TIKYAFMVNI PHIGFLFEHI
SKGAHAVNAS WWTNGYWSKR FIHAFFLQLF MNAEIFFFFN QWPCREMRSP KWKIAPLHNC
SVPLLLYLAH QAVHVGNAYH PLEAPSSYVK KFRYIKDLRR RIFAGMVAAL DQSVGDVFRA
LQRKGILEDT IVLLTSDSGG AAGGVEQGVG SNWPLRGTKK TLWEGGVRAV GLLWSAKLAR
GRVASQLIHR SAYFPLTNAD SCGDITDLGS IDGKDLWTVL VDDRPSPRTE LLYNIDYRWK
LAAIRVGPYK LVLGASSSDQ FDDWYEPIES DATNPYLESA ALRKALFTDC ALLAKLFYRL
QEFQLTNKPP LNRPPSPAAN PALHCNVWVP FMDSEVTGLR K
//
