ID B7QH07_IXOSC Unreviewed; 1310 AA.
AC B7QH07;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Cytoplasmic dynein heavy chain, putative {ECO:0000313|EMBL:EEC18129.1, ECO:0000313|EnsemblMetazoa:ISCW023533-PA};
GN ORFNames=IscW_ISCW023533 {ECO:0000313|EMBL:EEC18129.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC18129.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555}, and Wikel colony
RC {ECO:0000313|EMBL:EEC18129.1};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW023533-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW023533-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
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DR EMBL; ABJB010031952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010122153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010366523; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010372434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010495972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010706311; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010858667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010895566; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010923285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ABJB010960674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS935743; EEC18129.1; -; Genomic_DNA.
DR RefSeq; XP_002414464.1; XM_002414419.1.
DR STRING; 6945.B7QH07; -.
DR PaxDb; 6945-B7QH07; -.
DR EnsemblMetazoa; ISCW023533-RA; ISCW023533-PA; ISCW023533.
DR KEGG; isc:IscW_ISCW023533; -.
DR VEuPathDB; VectorBase:ISCI021659; -.
DR VEuPathDB; VectorBase:ISCP_002492; -.
DR VEuPathDB; VectorBase:ISCW023533; -.
DR HOGENOM; CLU_000038_1_1_1; -.
DR InParanoid; B7QH07; -.
DR OMA; ISHFYQF; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703:SF22; CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12781; AAA_9; 2.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 8..274
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 302..353
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 356..471
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 720..829
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 862..1000
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 1012..1307
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 163..246
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 414..441
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1310 AA; 146452 MW; F03CF6F8DDDAA418 CRC64;
MEMEALKEKM EQENKKLSKR KKEIDLELAQ IEPLIQEAKA AVGSIKSDAL SEIRSLRAPP
DVIRDILEGV LRLMGIFDTS WVSMKSFLAK RGVKEEILGF DVRSVTPEIR QSVQELLVKN
QSSFDVKNAK RASAAAAPLA SWVQANVKYA EVLQKIGPLE AEQAKLKKNL STAERRMDKL
GSALEDVDQE VSRLRDRLNQ FTKEAAQIEI NLRSADETIG TAEEMVLQLE GEYQRWTKQL
AGMEEELSQL PRRCLLASAF LTYLPAQPEE VRGSFVGRWC QMLSLADFRL CSFLGSEKEQ
LTWKAEGLPA DPLSLENAVL LLQSPLCPFV IDPSSQATEW LKRHLKDLQL EVATQRIGDK
TVDYNENFKL FLVTQNASVV LPPFATSLVM TVNFTTTRAG LSEQLLQAVL GEEKPELERR
RSDLLREEED LRVRLSQLED SLLEQLVSSQ GDLLANRGLL SSLHRTKASS LGIEAALGES
HRLQEALDQE RKAYLPLAHF GSELYFLTRQ LVKLNHMYVF SLASFLRLFI SALKQSTSGN
KGEKHLKQVQ KSFLQLVYEH ICRSLFKKDR IAFSLHLVHG MFPHLFKENE WEVFTGMLVT
DAKFDKESVR AELPGWIEDE RALAVALLKN LFPELSSALQ LENQELWRGF AESSHCEREI
PEAVAKRLTL FQQTLLVQAL RPDRLVSALT LFVSRVLGLR ELSPQALNFQ RLHAAESGAT
EPILIVTSPS VDASQELLDV ANAVRGSNKY HQVSMGQGQM DLALEYLKTC AQEGSWLCLT
NLHLVTGWLP CLVKEIAALR PHQDFRLWLT TEAHPKFSSV LLEMCLKVTY EAPPGVKRNL
QRTYSGWTPQ TISVRGNLLC SQAYFVLAWF HAIVQERRTY IPQGWTKFYE FSLADLKAGA
DIVDRLCRKE SGTVEWEFLR GLFETAVYGG RVDNPFDMRV LRSYLGQFFD SAVVSGTPRS
KRNLAPSVAV PTAPDYEVHL KVIEQIADED SPAYFGLPSN IDRSVQRTLS AQAVSQLRTL
ARPSEAAGKL DVQGWSSELS PVLNLWKKLN QGSQLIQTRL PATSDPPEGS RQSPIESFLK
LEHRSGIRLV QEIHATLASL SKVIRGTALL TAEVKEAATA LVNHQVPAQW LKRWEGPEEP
LPFLRGVVGR ALAVGGWIHK FDAGTLLRDP LELSDLFRPD TFLNALRQQT AREAHVPVDG
LHFVTSWKGG IAGATLTVTL SGLQLEGCSF DGSRLAQCRH NSPSVSSVPA CLAAWLPKSS
PAPYPEAGSI LLPLYSGVER EKVVATLSLP CDGDRNQWLQ CGAALFLKSV
//
