ID B7QJN4_IXOSC Unreviewed; 383 AA.
AC B7QJN4;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=REF-cotransformation assay oncogene, putative {ECO:0000313|EMBL:EEC19056.1, ECO:0000313|EnsemblMetazoa:ISCW023000-PA};
DE Flags: Fragment;
GN ORFNames=IscW_ISCW023000 {ECO:0000313|EMBL:EEC19056.1};
OS Ixodes scapularis (Black-legged tick) (Deer tick).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Ixodinae; Ixodes.
OX NCBI_TaxID=6945;
RN [1] {ECO:0000313|EMBL:EEC19056.1, ECO:0000313|Proteomes:UP000001555}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wikel {ECO:0000313|Proteomes:UP000001555};
RG Ixodes scapularis Genome Project Consortium;
RA Caler E., Hannick L.I., Bidwell S., Joardar V., Thiagarajan M., Amedeo P.,
RA Galinsky K.J., Schobel S., Inman J., Hostetler J., Miller J., Hammond M.,
RA Megy K., Lawson D., Kodira C., Sutton G., Meyer J., Hill C.A., Birren B.,
RA Nene V., Collins F., Alarcon-Chaidez F., Wikel S., Strausberg R.;
RT "Annotation of Ixodes scapularis.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:ISCW023000-PA}
RP IDENTIFICATION.
RC STRAIN=wikel {ECO:0000313|EnsemblMetazoa:ISCW023000-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABJB010160346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DS953432; EEC19056.1; -; Genomic_DNA.
DR RefSeq; XP_002415391.1; XM_002415346.1.
DR AlphaFoldDB; B7QJN4; -.
DR STRING; 6945.B7QJN4; -.
DR PaxDb; 6945-B7QJN4; -.
DR EnsemblMetazoa; ISCW023000-RA; ISCW023000-PA; ISCW023000.
DR KEGG; isc:IscW_ISCW023000; -.
DR VEuPathDB; VectorBase:ISCI023000; -.
DR VEuPathDB; VectorBase:ISCP_022256; -.
DR VEuPathDB; VectorBase:ISCW023000; -.
DR HOGENOM; CLU_052560_0_0_1; -.
DR InParanoid; B7QJN4; -.
DR OMA; STRKDCP; -.
DR Proteomes; UP000001555; Unassembled WGS sequence.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11400; bHLHzip_Myc; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR PANTHER; PTHR45851:SF3; MYC PROTEIN; 1.
DR PANTHER; PTHR45851; MYC PROTO-ONCOGENE; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000001555}.
FT DOMAIN 295..347
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 171..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..213
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EEC19056.1"
SQ SEQUENCE 383 AA; 43093 MW; B8721AC71391E489 CRC64;
YNLMEEFSSI PAPSDDIWKK FELLPTPPRS PDRSDDKIFD DHEDIVDEIL RSDVELFKPR
DSPVGWSSKT QTGELLHDCM WAGECAVNCT QKAAREKQDC NGVIVLKSTS SCEKCEPYEC
MGDAVATRCV DPSAVLAYTP LSDHCYHQPT LSTDSSIIND VCLSSAAASA QTAPSSATAH
HRAATSRSAR GHHYHPQQAH HHQRHHQQHH SQQNHHHQQP TSPPASRTTS SGRVVTPSQK
LLSNGSASRR KPSPRIETGR GSRARPPAAS EEVAPRREDL YASSCSSSDN PEDHERRKEH
NSMERKRRDD LRSAFQHLRL MVPSLRDNPK APKVMILNRA ADHARELTSQ SASVEDALRK
EVHRQRALRK RLAQLQQRNR KQR
//
