ID B7R2E3_9EURY Unreviewed; 453 AA.
AC B7R2E3;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE SubName: Full=Zinc-dependent protease, TldD/PmbA family {ECO:0000313|EMBL:EEB73752.1};
GN ORFNames=TAM4_40 {ECO:0000313|EMBL:EEB73752.1};
OS Thermococcus sp. AM4.
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Thermococcus.
OX NCBI_TaxID=246969 {ECO:0000313|EMBL:EEB73752.1, ECO:0000313|Proteomes:UP000009277};
RN [1] {ECO:0000313|EMBL:EEB73752.1, ECO:0000313|Proteomes:UP000009277}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AM4 {ECO:0000313|EMBL:EEB73752.1,
RC ECO:0000313|Proteomes:UP000009277};
RX PubMed=22123768; DOI=10.1128/JB.06259-11;
RA Oger P., Sokolova T.G., Kozhevnikova D.A., Chernyh N.A., Bartlett D.H.,
RA Bonch-Osmolovskaya E.A., Lebedinsky A.V.;
RT "Complete Genome Sequence of the Hyperthermophilic Archaeon Thermococcus
RT sp. Strain AM4, Capable of Organotrophic Growth and Growth at the Expense
RT of Hydrogenogenic or Sulfidogenic Oxidation of Carbon Monoxide.";
RL J. Bacteriol. 193:7019-7020(2011).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP002952; EEB73752.1; -; Genomic_DNA.
DR RefSeq; WP_014122679.1; NC_016051.1.
DR AlphaFoldDB; B7R2E3; -.
DR STRING; 246969.TAM4_40; -.
DR GeneID; 7418677; -.
DR KEGG; tha:TAM4_40; -.
DR eggNOG; arCOG00321; Archaea.
DR HOGENOM; CLU_026425_1_2_2; -.
DR OrthoDB; 98233at2157; -.
DR Proteomes; UP000009277; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR025502; TldD.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR30624:SF0; METALLOPROTEASE SLR0863; 1.
DR PANTHER; PTHR30624; UNCHARACTERIZED PROTEIN TLDD AND PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR PIRSF; PIRSF004919; TldD; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EEB73752.1}.
FT DOMAIN 22..82
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 108..214
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 221..448
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 453 AA; 49715 MW; 0499DDD54F2AE850 CRC64;
MEENLLKIAE RTAGKLDVEY FEIRISRVKT ASVLIQNDQV DELSNNVEVG IGVRAFRRGW
GFSSANDLSK AEEVIKTAMK MAGLSKGPEA IYLGDPIRDS VSNLGEKRLD EVDISEKLEL
TKRAAELLKG EGVKNRISSY GESVIETLYL NSLGSEIRTV SSRVRLRIAA TAFEAGKTGE
YWKSFGGTGG WELIERIELE RWADFVSRKA RELLRAKAPP SGKFDVIMDP ELTGVFIHEA
VGHAAEADAV KNGESIFSGR LGERIGVEEL NVVDDPTLPG KFGSYAYDDE GLPGKRVEII
KNGVLNEYLN DRETSALLGL VPNGHGRAQS YAHQPLVRMS NTYVEAGTWE PEEIFEEVRH
GLYMIGDKGG EVDVATGTFT FGAKEGYIVE NGELKVHLRD VSLSGNLLEV LRSIKAIGRD
VRIQFPGYCG KGQWVPVDDG GPHVLTEALV GGR
//
