ID   B7SP41_DERVA            Unreviewed;       204 AA.
AC   B7SP41;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Putative legumain-like protease {ECO:0000313|EMBL:ACF35523.1};
DE   Flags: Fragment;
OS   Dermacentor variabilis (American dog tick).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Parasitiformes; Ixodida; Ixodoidea; Ixodidae; Rhipicephalinae; Dermacentor.
OX   NCBI_TaxID=34621 {ECO:0000313|EMBL:ACF35523.1};
RN   [1] {ECO:0000313|EMBL:ACF35523.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=DvM 96 {ECO:0000313|EMBL:ACF35523.1};
RC   TISSUE=Midgut {ECO:0000313|EMBL:ACF35523.1};
RX   PubMed=19021911; DOI=10.1186/1471-2164-9-552;
RA   Anderson J.M., Sonenshine D.E., Valenzuela J.G.;
RT   "Exploring the mialome of ticks: an annotated catalogue of midgut
RT   transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae).";
RL   BMC Genomics 9:552-552(2008).
CC   -!- SIMILARITY: Belongs to the peptidase C13 family.
CC       {ECO:0000256|ARBA:ARBA00009941}.
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DR   EMBL; EU551626; ACF35523.1; -; mRNA.
DR   AlphaFoldDB; B7SP41; -.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd21115; legumain_C; 1.
DR   Gene3D; 1.10.132.130; -; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   InterPro; IPR048501; Legum_prodom.
DR   InterPro; IPR046427; Legumain_prodom_sf.
DR   InterPro; IPR001096; Peptidase_C13.
DR   PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR12000:SF42; LEGUMAIN; 1.
DR   Pfam; PF20985; Legum_prodom; 1.
DR   Pfam; PF01650; Peptidase_C13; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:ACF35523.1}.
FT   DOMAIN          101..195
FT                   /note="Legumain prodomain"
FT                   /evidence="ECO:0000259|Pfam:PF20985"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACF35523.1"
SQ   SEQUENCE   204 AA;  23411 MW;  4912CE8E30CE0FDF CRC64;
     NRHYGRGMED SDKEDLHKET LIDQFWIVRE ETNTSHVMEY GDLYIGKLPV GEFQGEEDAK
     PIVLPKVPYD AVSSRDVPIA VLRKKLAKAS DAQTKRSLKH KLQQALRNRS FLKEKVAEIA
     SFLPQGNEDS TESVLVAKRR LTKFDCYEHT VRYFNDRCFK LAKNPYALEQ LRVFVNVCES
     AYKLSEIFEA MDLACTHPTV VGIV
//