ID B7T9R0_CHEMY Unreviewed; 239 AA.
AC B7T9R0;
DT 10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT 10-FEB-2009, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ACJ48190.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:ACJ48190.1};
RN [1] {ECO:0000313|EMBL:ACJ48190.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CM_EasternPacific_1 {ECO:0000313|EMBL:ACJ48191.1},
RC CM_EasternPacific_2 {ECO:0000313|EMBL:ACJ48192.1}, and CM_Pacific
RC {ECO:0000313|EMBL:ACJ48190.1};
RX PubMed=18760371; DOI=10.1016/j.ympev.2008.08.004;
RA Naro-Maciel E., Le M., FitzSimmons N.N., Amato G.;
RT "Evolutionary relationships of marine turtles: A molecular phylogeny based
RT on nuclear and mitochondrial genes.";
RL Mol. Phylogenet. Evol. 49:659-662(2008).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; FJ039922; ACJ48190.1; -; Genomic_DNA.
DR EMBL; FJ039929; ACJ48191.1; -; Genomic_DNA.
DR EMBL; FJ039936; ACJ48192.1; -; Genomic_DNA.
DR AlphaFoldDB; B7T9R0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 128..235
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 136..203
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 181..232
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 191..234
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACJ48190.1"
FT NON_TER 239
FT /evidence="ECO:0000313|EMBL:ACJ48190.1"
SQ SEQUENCE 239 AA; 26821 MW; 979F5C96B1468B3F CRC64;
FLTMVISYFS CMKAAPMKEA SVRGLGSLAY PGLRTHGTLE SLSGPNTGSR GLTSLAGTFE
HVIEELLDEE QDVQPSEENK DADLYTSRVM LSSQVPLEPP LLFLLEEYKN YLDAANMSMR
VRRHSDPARR GELSVCDSTS EWVTAAEKKT AVDMSGATVT VLEKVPVPKG QLKQYFYETK
CNPKGYTKEG CRGIDKRHWN SQCRTTQSYV RALTMDNKKR VGWRFIRIDT SCVCTLTIK
//
