ID   B7Z2W3_HUMAN            Unreviewed;       597 AA.
AC   B7Z2W3;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=cDNA FLJ54432, highly similar to Alpha-actinin-1 {ECO:0000313|EMBL:BAH11999.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH11999.1};
RN   [1] {ECO:0000313|EMBL:BAH11999.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAH11999.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AK295175; BAH11999.1; -; mRNA.
DR   AlphaFoldDB; B7Z2W3; -.
DR   IntAct; B7Z2W3; 1.
DR   MINT; B7Z2W3; -.
DR   PeptideAtlas; B7Z2W3; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 3.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF434; ALPHA-ACTININ-1; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF13405; EF-hand_6; 1.
DR   Pfam; PF00435; Spectrin; 3.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM00150; SPEC; 3.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 3.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          377..412
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          61..95
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   597 AA;  67143 MW;  12CD80F424B81ED5 CRC64;
     MSGPCPSTRP RAAAPTTWIP PTSLALLHRH LPTTTRAAEG RQSKEAMLRQ KDYETATLSE
     IKALLKKHEA FESDLAAHQD RVEQIAAIAQ ELNELDYYDS PSVNARCQKI CDQWDNLGAL
     TQKRREALER TEKLLETIDQ LYLEYAKRAA PFNNWMEGAM EDLQDTFIVH TIEEIQGLTT
     AHEQFKATLP DADKERLAIL GIHNEVSKIV QTYHVNMAGT NPYTTITPQE INGKWDHVRQ
     LVPRRDQALT EEHARQQHNE RLRKQFGAQA NVIGPWIQTK MEEIGRISIE MHGTLEDQLS
     HLRQYEKSIV NYKPKIDQLE GDHQLIQEAL IFDNKHTNYT MEHIRVGWEQ LLTTIARTIN
     EVENQILTRD AKGISQEQMN EFRASFNHFD RDHSGTLGPE EFKACLISLG YDIGNDPQVL
     ASCMEHAQGW RLGQEIMRFS FFSSLCLDLL SPSCGPWGSS SPAVSVCPIT GPPSALCCLS
     WQPTGCPLSS VLAALHPMGG FLHLPALSSS CLWTFPPMCV RIFSYVPLPI LTPKTINLIP
     VLAICSCLPG PGPALPLPAF PTLLVSWYHC PPQKKTGMMD TDDFRACLIS MGYNMVT
//