ID   B7ZAY6_HUMAN            Unreviewed;       342 AA.
AC   B7ZAY6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=cDNA, FLJ79350, highly similar to Protein transport protein Sec24C {ECO:0000313|EMBL:BAH14822.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAH14822.1};
RN   [1] {ECO:0000313|EMBL:BAH14822.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAH14822.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
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DR   EMBL; AK316451; BAH14822.1; -; mRNA.
DR   AlphaFoldDB; B7ZAY6; -.
DR   PeptideAtlas; B7ZAY6; -.
DR   GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR   Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR   Gene3D; 3.40.20.10; Severin; 1.
DR   InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR   InterPro; IPR007123; Gelsolin-like_dom.
DR   InterPro; IPR036180; Gelsolin-like_dom_sf.
DR   InterPro; IPR006900; Sec23/24_helical_dom.
DR   InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR   InterPro; IPR012990; Sec23_24_beta_S.
DR   PANTHER; PTHR13803:SF5; PROTEIN TRANSPORT PROTEIN SEC24C; 1.
DR   PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR   Pfam; PF00626; Gelsolin; 1.
DR   Pfam; PF08033; Sec23_BS; 1.
DR   Pfam; PF04815; Sec23_helical; 1.
DR   SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR   SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR   SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329}.
FT   DOMAIN          1..79
FT                   /note="Sec23/Sec24 beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF08033"
FT   DOMAIN          92..191
FT                   /note="Sec23/Sec24 helical"
FT                   /evidence="ECO:0000259|Pfam:PF04815"
FT   DOMAIN          210..283
FT                   /note="Gelsolin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00626"
SQ   SEQUENCE   342 AA;  38154 MW;  1CC80EE8466C4E68 CRC64;
     MRVRTSTGIR AVDFFGAFYM SNTTDVELAG LDGDKTVTVE FKHDDRLNEE SGALLQCALL
     YTSCAGQRRL RIHNLALNCC TQLADLYRNC ETDTLINYMA KFAYRGVLNS PVKAVRDTLI
     TQCAQILACY RKNCASPSSA GQLILPECMK LLPVYLNCVL KSDVLQPGAE VTTDDRAYVR
     QLVTSMDVTE TNVFFYPRLL PLTKSPVEST TEPPAVRASE ERLSNGDIYL LENGLNLFLW
     VGASVQQGVV QSLFSVSSFS QITSGLSVLP VLDSPLSKKV RGLIDSLRAQ RSRYMKLTVV
     KQEDKMEMLF KHFLVEDKSL SGGASYVDFL CHMHKEIRQL LS
//