ID B7ZD17_DANRE Unreviewed; 457 AA.
AC B7ZD17; A0A8M1PAA0;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Noelin isoform 2 precursor {ECO:0000313|RefSeq:NP_001315344.1};
DE SubName: Full=Olfactomedin 1b {ECO:0000313|Ensembl:ENSDARP00000119769};
GN Name=olfm1b {ECO:0000313|Ensembl:ENSDARP00000119769,
GN ECO:0000313|RefSeq:NP_001315344.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040801-228};
GN Synonyms=si:ch211-11g18.1 {ECO:0000313|RefSeq:NP_001315344.1},
GN wu:fd59h02 {ECO:0000313|RefSeq:NP_001315344.1}, zgc:92039
GN {ECO:0000313|RefSeq:NP_001315344.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000119769};
RN [1] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=16631158;
RA Cheng W., Guo L., Zhang Z., Soo H.M., Wen C., Wu W., Peng J.;
RT "HNF factors form a network to regulate liver-enriched genes in
RT zebrafish.";
RL Dev. Biol. 294:482-496(2006).
RN [2] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=17681890;
RA Nakaya N., Tomarev S.;
RT "Expression patterns of alternative transcripts of the zebrafish
RT olfactomedin 1 genes.";
RL Gene Expr. Patterns 7:723-729(2007).
RN [3] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=18667622;
RA Nakaya N., Lee H.S., Takada Y., Tzchori I., Tomarev S.I.;
RT "Zebrafish olfactomedin 1 regulates retinal axon elongation in vivo and is
RT a modulator of Wnt signaling pathway.";
RL J. Neurosci. 28:7900-7910(2008).
RN [4] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=21965609;
RA Madelaine R., Garric L., Blader P.;
RT "Partially redundant proneural function reveals the importance of timing
RT during zebrafish olfactory neurogenesis.";
RL Development 138:4753-4762(2011).
RN [5] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=21052758;
RA Wang Y., Zhang S.;
RT "Identification and expression of liver-specific genes after LPS challenge
RT in amphioxus: the hepatic cecum as liver-like organ and 'pre-hepatic' acute
RT phase response.";
RL Funct. Integr. Genomics 11:111-118(2011).
RN [6] {ECO:0000313|Ensembl:ENSDARP00000119769, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119769};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000119769}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000119769};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [9] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=27605615;
RA Moravec C.E., Samuel J., Weng W., Wood I.C., Sirotkin H.I.;
RT "Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b.";
RL J. Neurosci. 36:9407-9419(2016).
RN [10] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=28975619;
RA Nakaya N., Sultana A., Tomarev S.I.;
RT "Impaired AMPA receptor trafficking by a double knockout of zebrafish
RT olfactomedin1a/b.";
RL J. Neurochem. 143:635-644(2017).
RN [11] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [12] {ECO:0000313|RefSeq:NP_001315344.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RX PubMed=30060229;
RA Wu X., Shen W., Zhang B., Meng A.;
RT "The genetic program of oocytes can be modified in vivo in the zebrafish
RT ovary.";
RL J. Mol. Cell Biol. 10:479-493(2018).
RN [13] {ECO:0000313|RefSeq:NP_001315344.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001315344.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AL929085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001315344.1; NM_001328415.1.
DR Ensembl; ENSDART00000146371; ENSDARP00000119769; ENSDARG00000014053.
DR Ensembl; ENSDART00000146371.3; ENSDARP00000119769.1; ENSDARG00000014053.10.
DR GeneID; 445092; -.
DR AGR; ZFIN:ZDB-GENE-040801-228; -.
DR CTD; 445092; -.
DR ZFIN; ZDB-GENE-040801-228; olfm1b.
DR OrthoDB; 2876896at2759; -.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000014053; Expressed in liver and 43 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR022082; Noelin_dom.
DR InterPro; IPR003112; Olfac-like_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR PANTHER; PTHR23192:SF34; NOELIN; 1.
DR PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR Pfam; PF12308; Noelin-1; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS51132; OLF; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00446}; Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..457
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001315344.1"
FT /id="PRO_5035035716"
FT DOMAIN 198..450
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT COILED 66..114
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 150..196
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 199..381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 457 AA; 52495 MW; 888B46AF57C0C363 CRC64;
MQRVHKLLSL IVLVLMGTEL TQVLPANPEE SWQVYSSAQD SEGRCVCTVV APQQTMCSRD
ARTKQLRQLL EKVQNMTQSI QVLDQRTQRD LQYVVKMEDQ LRGLETKFRQ VEENHKQNIA
KQYKAIKAKM AELRPLIPVL EEYKADARLV QQFKEEVQNL TASLGLLQQE MGAYDYDDLH
SRVVSLEERL RACMQKLACG KLTGISDAIT IKTSGSRFGS WMTDPLAPEG DTRVWYMDGY
HNNRFVREYK SMADFMTSDN FTSHRLPHPW SGTGQVVYNG SIYFNKFQSN MIIKFDFKTS
TMSKSQRLDN AGFSNTYHYA WGGHSDIDLM VDEGGLWAVY ATNQNAGNIV ISKLHPITLH
IIQSWTTNHP RRSAGESFMI CGTLYVTNGY SGGTKVYYAY HTNSSTYEYI DIVLQNKYSH
ISMLDYNPRD RALYAWNNGH QVLYNVTLFH VIRSEQL
//
