ID   B7ZQ94_XENLA            Unreviewed;       778 AA.
AC   B7ZQ94;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   13-SEP-2023, entry version 56.
DE   RecName: Full=Pendrin {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Sodium-independent chloride/iodide transporter {ECO:0000256|RuleBase:RU362052};
DE   AltName: Full=Solute carrier family 26 member 4 {ECO:0000256|RuleBase:RU362052};
GN   Name=pendrin {ECO:0000313|EMBL:AAI69726.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAI69726.1};
RN   [1] {ECO:0000313|EMBL:AAI69726.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000313|EMBL:AAI69726.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sodium-independent transporter of chloride and iodide.
CC       {ECO:0000256|RuleBase:RU362052}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC   -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC       {ECO:0000256|RuleBase:RU362052}.
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DR   EMBL; BC169726; AAI69726.1; -; mRNA.
DR   EMBL; BC169728; AAI69728.1; -; mRNA.
DR   AlphaFoldDB; B7ZQ94; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR   Gene3D; 3.30.750.24; STAS domain; 1.
DR   InterPro; IPR018045; S04_transporter_CS.
DR   InterPro; IPR011547; SLC26A/SulP_dom.
DR   InterPro; IPR001902; SLC26A/SulP_fam.
DR   InterPro; IPR002645; STAS_dom.
DR   InterPro; IPR036513; STAS_dom_sf.
DR   NCBIfam; TIGR00815; sulP; 1.
DR   PANTHER; PTHR11814:SF33; PENDRIN; 1.
DR   PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR   Pfam; PF01740; STAS; 1.
DR   Pfam; PF00916; Sulfate_transp; 1.
DR   SUPFAM; SSF52091; SpoIIaa-like; 1.
DR   PROSITE; PS01130; SLC26A; 1.
DR   PROSITE; PS50801; STAS; 1.
PE   2: Evidence at transcript level;
KW   Chloride {ECO:0000256|RuleBase:RU362052};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362052};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT   TRANSMEM        99..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        186..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        213..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        242..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        265..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        295..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        340..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        380..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        444..461
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   TRANSMEM        476..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362052"
FT   DOMAIN          530..727
FT                   /note="STAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50801"
FT   REGION          597..626
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..622
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   778 AA;  85872 MW;  E3637CF5C9663844 CRC64;
     MATARMDIPS PGYNQYLVHR SVYSEPTFQE ENERKEPVRK TLQDRVKKNC SCTSKKALFI
     VKKFLPILNW LPKYRWKEWF LSDLISGVST GLVGTLQGLA FALLAAVPVG YGLYSSFFPI
     LTYFFLGTSK HISVGPFPVV SLMVGSVVLS IAPDEKFAIL GNSTGLNKTI IDTVARDAAR
     VAVSGTLSFL IGIIQLALGV FQIGFIIRYL ADPLVGGFTT AAAFQVFVSQ FKLVLNVPTK
     NYNGVLSIIY TIIDIFTNIA KTNIADLIAG LLTFVVCVVV KEINDRYKRI FRVPIPIEVI
     VTIVATGISY GVNLEKKYNA GIVKTIPTGF IPPMTPDVSL FSQIGSSAFS IGIVAYAVAV
     SVGKVYATKH NYEVDGNQEF IAFGISNLFG GVFSCFCATT ALSRTAIQES TGGKTQIAGI
     ISAGIVLIAI VALGKLLEPL QKSVLAAIVI ANLKGMFWQV FDVPRLWKQN KWDSVIWVFT
     CIASILLGLD LGLLAGLLFG LVTIILRVQF PSCGALGSVP GTDIYKNVKE YKNLIEPEGV
     KIIRYTSGMF YGNIDGFKNA IKSIVGFDAV KVYNKRTKAL RKIQKLIKKG QLRSTKNGII
     SSTGADNEGY EPDDDPEDPE QENNEAVQTK EVEIQVDWNS ELPIKVSVPK VSIHSIIFDF
     GQIHFIDVVA VRSLKVIFKE FKRIDVEPYI AAYEDGVLQK MEKCFFFDEV IKLDIFFLTV
     HDAVLHIENL RKFYDGHDPL LEKISLMQES KEPLEFTTTD PTDQELDAQE GALRSLAH
//