ID B8CCU8_THAPS Unreviewed; 1253 AA.
AC B8CCU8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Potassium channel domain-containing protein {ECO:0000259|Pfam:PF07885};
GN ORFNames=THAPSDRAFT_24939 {ECO:0000313|EMBL:EED88838.1};
OS Thalassiosira pseudonana (Marine diatom) (Cyclotella nana).
OC Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC Coscinodiscophyceae; Thalassiosirophycidae; Thalassiosirales;
OC Thalassiosiraceae; Thalassiosira.
OX NCBI_TaxID=35128 {ECO:0000313|EMBL:EED88838.1, ECO:0000313|Proteomes:UP000001449};
RN [1] {ECO:0000313|EMBL:EED88838.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED88838.1};
RX PubMed=15459382; DOI=10.1126/science.1101156;
RA Armbrust E.V., Berges J.A., Bowler C., Green B.R., Martinez D.,
RA Putnam N.H., Zhou S., Allen A.E., Apt K.E., Bechner M., Brzezinski M.A.,
RA Chaal B.K., Chiovitti A., Davis A.K., Demarest M.S., Detter J.C.,
RA Glavina T., Goodstein D., Hadi M.Z., Hellsten U., Hildebrand M.,
RA Jenkins B.D., Jurka J., Kapitonov V.V., Kroger N., Lau W.W., Lane T.W.,
RA Larimer F.W., Lippmeier J.C., Lucas S., Medina M., Montsant A., Obornik M.,
RA Parker M.S., Palenik B., Pazour G.J., Richardson P.M., Rynearson T.A.,
RA Saito M.A., Schwartz D.C., Thamatrakoln K., Valentin K., Vardi A.,
RA Wilkerson F.P., Rokhsar D.S.;
RT "The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and
RT metabolism.";
RL Science 306:79-86(2004).
RN [2] {ECO:0000313|EMBL:EED88838.1, ECO:0000313|Proteomes:UP000001449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCMP1335 {ECO:0000313|EMBL:EED88838.1};
RX PubMed=18923393; DOI=10.1038/nature07410;
RA Bowler C., Allen A.E., Badger J.H., Grimwood J., Jabbari K., Kuo A.,
RA Maheswari U., Martens C., Maumus F., Otillar R.P., Rayko E., Salamov A.,
RA Vandepoele K., Beszteri B., Gruber A., Heijde M., Katinka M., Mock T.,
RA Valentin K., Verret F., Berges J.A., Brownlee C., Cadoret J.P.,
RA Chiovitti A., Choi C.J., Coesel S., De Martino A., Detter J.C., Durkin C.,
RA Falciatore A., Fournet J., Haruta M., Huysman M.J., Jenkins B.D.,
RA Jiroutova K., Jorgensen R.E., Joubert Y., Kaplan A., Kroger N., Kroth P.G.,
RA La Roche J., Lindquist E., Lommer M., Martin-Jezequel V., Lopez P.J.,
RA Lucas S., Mangogna M., McGinnis K., Medlin L.K., Montsant A.,
RA Oudot-Le Secq M.P., Napoli C., Obornik M., Parker M.S., Petit J.L.,
RA Porcel B.M., Poulsen N., Robison M., Rychlewski L., Rynearson T.A.,
RA Schmutz J., Shapiro H., Siaut M., Stanley M., Sussman M.R., Taylor A.R.,
RA Vardi A., von Dassow P., Vyverman W., Willis A., Wyrwicz L.S.,
RA Rokhsar D.S., Weissenbach J., Armbrust E.V., Green B.R., Van de Peer Y.,
RA Grigoriev I.V.;
RT "The Phaeodactylum genome reveals the evolutionary history of diatom
RT genomes.";
RL Nature 456:239-244(2008).
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DR EMBL; CM000649; EED88838.1; -; Genomic_DNA.
DR RefSeq; XP_002293829.1; XM_002293793.1.
DR AlphaFoldDB; B8CCU8; -.
DR PaxDb; 35128-Thaps24939; -.
DR EnsemblProtists; EED88838; EED88838; THAPSDRAFT_24939.
DR GeneID; 7441839; -.
DR KEGG; tps:THAPSDRAFT_24939; -.
DR eggNOG; KOG1418; Eukaryota.
DR HOGENOM; CLU_265608_0_0_1; -.
DR InParanoid; B8CCU8; -.
DR OMA; MHELKGD; -.
DR Proteomes; UP000001449; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR47823; ION_TRANS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47823:SF9; K+-CHANNEL ERG AND RELATED PROTEINS; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001449};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 262..283
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 281..347
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 427..495
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 1..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1230..1253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1253 AA; 139938 MW; 9F954C725C2889FF CRC64;
MASNSPRHDV EPVAISSELN DGASTLTSSA APSPSPPVDS DDGGGETGSN VDGDPLPTNS
FVDDNTGSLR GSIMVSQGRM QSSTTHAQDD SNLPQSYYEP MTRKQSRTIP KSASYRSFLQ
QRTNNSISTA DSAQDGGDNN SEHSVPQSES SEVSFTNHLQ TRIEEWSSKT KGFFSKRAVD
LIDQSGHAKA RHRRRSSIDS TTQRAVDTDL NDVGADGAAC PMKSPSDTTA SLDEEEWFYY
KDFSFYSLKV DSKYPWMRNA GVFSILTTLL FYIFSPILWC HILQDENICP SSESGRYNGW
LTSLYFASAT MSTVGYGDVT VLVGDDSDNT ENWRIFIAVL FMILSLIASV IGLQAGLDSH
FHPFRRRLDV FVTRVFEILK DANVIKGTYD KHEDVMSRMR WLKFTQLVEI LLIFVALNLV
GVFALRLSLL GETEDELGSK LSLSWMESLY WAVQTTTTIG YGDVETPDNF RWFMIIYLSI
STYFVGNAIG KLGELNDKLE SMRKMYLWEQ QEASYEMLAD FSGRGSENGD GEFVDVEPEI
DQFEFTIASL VLMGKISSAD VAPIIEKFKK LTGRNGSKIT AADVSGPMKK KEELTDIAIT
EDSMSKEEPN IPQFPSKPSP STPNALVVAK KVAQAFREEV LSSTVVQEKE APTQEVEIVV
DYSSFCLPNK TFAIAIDDSK IQRKLLSKYL DFAGIPQDHC TIVGDGRDEI MGFEDFVVNF
MESQDDDVVN EDSSRHETIS GSLCVESIRK RLPNKLEKRM FALVRSANDS SSDIAIYNAR
AHGFLPKAPV KRDKVVETLA PMWLKRFPPS EFGMSVAGGK TSNDATSIVP DDIACSPYEI
SQKLDDIEAL FKKDVRVTDV HTIHDQMHEL KGDILTLNGN ISVTSIVGLI NLILVAKTPE
MILEKWKALH ERVKDIVDSM QKNFCIPKNV FAIAIDDSKI QRKLMEKFFT NAGIPKDQQT
ILGDGRDEIV GFEDFAVKFI ESHLNKDYIF MVVDENLDVE NDGPSKHEAI SGSLCVENIR
RRLSPDAERR VLALVRSAND STSDVSIYNK RAHGFLPKAP IRREKINETL APLWMKRFPL
SEFGSSGVFD TRDDASSVAS DDIACSPRDI KTKLGDIDTL FEKNVHVDNW RKIHDVMHEL
KGDLLTLHSN ASMISILGMI NLMMQASNSP DSTLEKWKAL RDRIMSLIES LQRGSSQRKI
VLQSSLTRRI IRRSSVTRSF TKESSSFMNT FASTSPNNSN DFQTSEVMEE TLK
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