ID B8G2Y9_CHLAD Unreviewed; 807 AA.
AC B8G2Y9;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase NAD-binding {ECO:0000313|EMBL:ACL23293.1};
GN OrderedLocusNames=Cagg_0347 {ECO:0000313|EMBL:ACL23293.1};
OS Chloroflexus aggregans (strain MD-66 / DSM 9485).
OC Bacteria; Chloroflexota; Chloroflexia; Chloroflexales; Chloroflexineae;
OC Chloroflexaceae; Chloroflexus.
OX NCBI_TaxID=326427 {ECO:0000313|EMBL:ACL23293.1, ECO:0000313|Proteomes:UP000002508};
RN [1] {ECO:0000313|Proteomes:UP000002508}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-66 / DSM 9485 {ECO:0000313|Proteomes:UP000002508};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Pitluck S., Foster B., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Bryant D.A., Richardson P.;
RT "Complete sequence of Chloroflexus aggregans DSM 9485.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
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DR EMBL; CP001337; ACL23293.1; -; Genomic_DNA.
DR RefSeq; WP_012615659.1; NC_011831.1.
DR AlphaFoldDB; B8G2Y9; -.
DR STRING; 326427.Cagg_0347; -.
DR KEGG; cag:Cagg_0347; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_0; -.
DR OrthoDB; 9771883at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000002508; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..204
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 208..307
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 508..639
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 807 AA; 88540 MW; 7FFB881A492FB563 CRC64;
MTYHIKRVGV IGAGTMGAAI AALVAGTGIP VLLLDVPPRS LTPDEEAKGL TLSHPQVRNR
IVQQGFERMR KARPSNLYTE RSAELITLGN TEDDFHRLAE CDWIVEAIVE QIGPKQALMA
RLEEVRKPTA IITTNTSGIP IRIIAEGRSE AFRRHFFGSH FFNPPRYLRL LEIIPGDDAD
PTVVAAFRQF AEERLGKGVV ICKDRPNFIG NRIFVYAGQV LLNFALQHGY QVEEVDALTG
PLIGRPNTAS FRLLDQVGID VMAYVAGNLY DAIPDDESRE VYRQNDLTQR MVAAGKLGKK
VGQGFYKEMK RDGKREFWPI DLQTLEYIPP QGTASVDALI AAARKIKSLP ERLRFILSKA
ETEHDRGAQL VAAAMYPMMA YAARRLPEIA DSVADVDNAM RWGFAHEQGP FQLWQAMGIA
ETAARMRTFG ETLPAWVDEL IKAEGRFYGE IDGQPAAYNV ATGKLEPISR DPRAIDLAAL
KAAGRELFGN DSASVIDLGD GVLCFELHSK ANTIGGPVIE TLIKALDELE QGPWVGMVIG
NQGPRFSAGL DLNDVGAAVM AGAWDDIDEY AALVQQTFRR MRDSAKPVVS APFGQTLGGG
VELSMHTAAS VAAAETYMGF VEFGVGVIPA WGGCTEMNRR IIATAARNGH DPLKAFQQVF
ETIALAKVAT SAHEAKELGL LRPTDRIVFN PDYLIGEAKR EVLRLVADGY TPTISAKPCY
ALGRDGLAAA RIAIYQMREA GFATPYDAVL AEKLAYVLCG GELSSPQWVD DVYMHSLERI
TVIELLKDER TQARARHMLE HGKPLRN
//
