ID B8HWM5_CYAP4 Unreviewed; 912 AA.
AC B8HWM5;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Signal transduction histidine kinase {ECO:0000313|EMBL:ACL46451.1};
GN OrderedLocusNames=Cyan7425_4137 {ECO:0000313|EMBL:ACL46451.1};
OS Cyanothece sp. (strain PCC 7425 / ATCC 29141).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Gomontiellales; Cyanothecaceae;
OC Cyanothece.
OX NCBI_TaxID=395961 {ECO:0000313|EMBL:ACL46451.1};
RN [1] {ECO:0000313|EMBL:ACL46451.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PCC 7425 {ECO:0000313|EMBL:ACL46451.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Meineke L., Brettin T.,
RA Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Ovchinnikova G., Liberton M., Stoeckel J., Banerjee A., Singh A., Page L.,
RA Sato H., Zhao L., Sherman L., Pakrasi H., Richardson P.;
RT "Complete sequence of chromosome Cyanothece sp. PCC 7425.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001344; ACL46451.1; -; Genomic_DNA.
DR AlphaFoldDB; B8HWM5; -.
DR STRING; 395961.Cyan7425_4137; -.
DR KEGG; cyn:Cyan7425_4137; -.
DR eggNOG; COG2202; Bacteria.
DR eggNOG; COG3920; Bacteria.
DR eggNOG; COG5002; Bacteria.
DR HOGENOM; CLU_000445_114_10_3; -.
DR OrthoDB; 567946at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd00130; PAS; 2.
DR CDD; cd12913; PDC1_MCP_like; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR011495; Sig_transdc_His_kin_sub2_dim/P.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR41523:SF7; ETHYLENE RESPONSE SENSOR PROTEIN; 1.
DR PANTHER; PTHR41523; TWO-COMPONENT SYSTEM SENSOR PROTEIN; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF07568; HisKA_2; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13188; PAS_8; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 2.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACL46451.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 371..424
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 433..470
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 513..562
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 570..640
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
SQ SEQUENCE 912 AA; 102378 MW; A247119F925E60FC CRC64;
MAAVSRPRVP QVKHHWTMPL HWVLVVPFVV LISGSVGLVG YLSYRSGEQA VQDLVHQLQN
EKSLRIVQHL DNYLSIPQKI NQTNLEAIEL GILDLQNFET TGKYFWRQLH IFHVGYINYG
NEAGEFIGAG YEEGKLRISE KKHNQPYQIF AANPQGDRLS VVQTKPEGNP NAADWYTDAL
KAGQPIWSQI YNWQDDPSVM AISASYPVYN SRQQVIGVIG VDLILSQISK FLQTIQVTAS
GRTFILEQNG LLVASSSNEA PFRMVNGEAR RLAANDSQDP VVNFVTRKLE QQFGSWRNLD
QQTQLNTTFE GERYFIQVTP WRDPLGLDWL VVVVVPETEF MGQIQANTRT TILLCALTLG
LALLLGLLTA RWVATPIAQL SQASYAMAAG AKQQPLPTQT AITELQTLAE AFELMSAQVY
QSLDRVKIAL QESKEKYQTL FQTLPMGIAI TDAKGKLLES NPASERILGI PIDVQTQRTH
DAPDWQIIRP DGSPMPPTEF ASVRALQENR YVANVEMGVV QPDGQIRWIS VSATPIPLEH
YGVAIAYIDI TERKQQEAER KTAELALKEK TAELDYFFSA ALDLLCIANT DGYFLRLNPQ
WQVCLGYSLS DLEGKRFLDF VHPEDLQATL AAIGQLSQQQ PILNFTNRYR HQDGSYRWIE
WRSVPQGDLI YSAARDITER KQTEAQIQAA LAEKVTLLQE VHHRVKNNLQ VICSLLRLQK
NRIKDAQISS VLEDSNNRIL SMALVHQSLY ESQNFAQVNL ADYVQALLQS LLQSYGGRSG
QVNTQIQIPA TAFVRLDQAV PCGLILNELI TNAFKHGFAD PDRSGQIQIT LTIEESETIE
ERGSYVLRVA NNGKPLPPGF SLEQSRRSLG MQLMLVLTEQ LQGRLVLEQH ADRAGDLTIF
ALHFGPNPAK YN
//
