ID B8I9I9_METNO Unreviewed; 907 AA.
AC B8I9I9;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Mnod_0197 {ECO:0000313|EMBL:ACL55242.1};
OS Methylobacterium nodulans (strain LMG 21967 / CNCM I-2342 / ORS 2060).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylobacterium.
OX NCBI_TaxID=460265 {ECO:0000313|EMBL:ACL55242.1, ECO:0000313|Proteomes:UP000008207};
RN [1] {ECO:0000313|EMBL:ACL55242.1, ECO:0000313|Proteomes:UP000008207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21967 / CNCM I-2342 / ORS 2060
RC {ECO:0000313|Proteomes:UP000008207};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Marx C.J.,
RA Richardson P.;
RT "Complete sequence of chromosome of Methylobacterium nodulans ORS 2060.";
RL Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP001349; ACL55242.1; -; Genomic_DNA.
DR RefSeq; WP_015926955.1; NC_011894.1.
DR AlphaFoldDB; B8I9I9; -.
DR STRING; 460265.Mnod_0197; -.
DR KEGG; mno:Mnod_0197; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_113_1_5; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000008207; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:ACL55242.1};
KW Ion transport {ECO:0000313|EMBL:ACL55242.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ACL55242.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008207};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:ACL55242.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 408..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 679..896
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 907 AA; 97698 MW; AB4FC816482F5BBB CRC64;
MSEPRRDPTR PSPDALLAAA RREEGRRGRL KVFLGAAPGV GKTYEMLTIG RARRKAGADV
VVGIVETHGR AETEVLLEGF EVIPRRRVPY RGTLLEEMDL DALLARRPAL ALVDELAHTN
APGSRHPKRY QDVEELLDAG IDVLTTLNIQ HVESLNDVVA SITRIRVRET VPDSILDRAD
DIEVVDLNPD DLIQRLKDGK VYVPQNAERA LKHYFSRGNL TALRELALRC TADRVDDELL
SHMRANAIAG PWGAGERVLV CVGEDPRAAG LVRYAKRLAD RLHAPWTALT VEGPRSPSLS
EAERDRIADT LRLADRLGGD TVTIPGGRRI AEDILAYARS ANVNHVVVGK SDRSWLFELM
HGSVVHDLVR RSGTISVHVV AGEAAEAAPV PRKTVATMAA TPAWGPRPYA VALLAVAAAL
GVALLGQPYV GVENSNLFLL SSVVAVAVRY GLGPSLLAVV AASLSYNFFF LPPVYTFTIA
DPTNVAAFVL FTVVAVLVSN LAARSQRVAA VAQARARATE RLYGFSRKLA SCGTLDDVLW
ATCAQVAAML KVRVVLLLPE QDGLAVRAGY PPEDMLDDAD VAAAKWAFDN DRSAGRGADT
LPGAKRLFLP MRTGRGTIGV IGLDADGTGP ILTPEGRRLL DALADQGALA IERVRLVEDL
DRAERAAETD RLRQALLTSM SHDLRTPLAS VLGAATTLRD LDEALAPEAK RDLLATIIAE
SERLNRFIAN LLDMTRLEAG AVAPNLAPHD IGETVGTALR RTEAMLAGHR VAIDVPADLP
ALRLDPVLFE QVLVNLLDNA AKYAPEGSTV TIRGWREGSL VRLQVLDEGE GLPEAEIERV
FDKFYRVRKG DRVRAGTGLG LSIARGFVEA MGGALVAANR PDRPGAAFTL TLPVPAKDRD
AAPEIAA
//
