ID B8LV44_TALSN Unreviewed; 567 AA.
AC B8LV44;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Cytochrome P450 monooxygenase, putative {ECO:0000313|EMBL:EED23094.1};
GN ORFNames=TSTA_065490 {ECO:0000313|EMBL:EED23094.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED23094.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971,
CC ECO:0000256|PIRSR:PIRSR602403-1};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617}.
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DR EMBL; EQ962652; EED23094.1; -; Genomic_DNA.
DR RefSeq; XP_002340481.1; XM_002340440.1.
DR AlphaFoldDB; B8LV44; -.
DR STRING; 441959.B8LV44; -.
DR GeneID; 8102698; -.
DR VEuPathDB; FungiDB:TSTA_065490; -.
DR eggNOG; KOG0157; Eukaryota.
DR HOGENOM; CLU_001570_5_11_1; -.
DR InParanoid; B8LV44; -.
DR OMA; TCLEYRK; -.
DR OrthoDB; 2954533at2759; -.
DR PhylomeDB; B8LV44; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR CDD; cd11069; CYP_FUM15-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24305; CYTOCHROME P450; 1.
DR PANTHER; PTHR24305:SF227; P450, PUTATIVE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00465; EP450IV.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|PIRSR:PIRSR602403-1};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR602403-1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602403-1};
KW Monooxygenase {ECO:0000313|EMBL:EED23094.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 28..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT BINDING 513
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR602403-1"
SQ SEQUENCE 567 AA; 64542 MW; CBB19E6F7D7851CA CRC64;
MVSWSLVAVV AAIFTVKFAP EYSLYSSYLL TSTTFILISW IAKFVYAAIL YPAYLTPLRQ
IPTPSKRSWM YGNTESFDLR FPVDLVREWT KSIPNPGLLR YYVIGNWERV VVLSPKAIAD
LLVNKSYDFV RPEIARVQLS KVTGEGLLVA EGDAHKAQRK SLMPSFSYRH IKELYPVFWT
KAIQMTNEIE KGIKTNKSGE DIIKTSGWAS RAMLDIIGLA GFDYDFNTVA NPDNELARRY
ESMFFTPTGW QRVIAFVCLF IIGFKWYFRI PSRQNSIMDD AMSFIRGTAH EHLTKKKKQL
QTDRKDAHVD ILSVAMRNGD FTDENLVNQM MTFLGAGHET TSSAFQWAVY VLSKHPEIQT
RLREELQASL PRIPFDELND IKGLKDNQGN IKDTFSELFT SIDGNNNTNI PYLWAFTNEV
LRFYPSAPFT SREAIRNTTL GGQFIPKGTH ILVAPDITNK DTELWGPDAE TFKPERWLNF
DPASSNKPVS YNNSGGASSN YAMLTFIHGP RSCIGQGFAR AELAIFVAVF VYRFRFELED
PGRKLEVRRM ITQAPADGVV IRVRMAN
//
