ID B8LVS3_TALSN Unreviewed; 641 AA.
AC B8LVS3;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Efflux pump antibiotic resistance protein, putative {ECO:0000313|EMBL:EED24203.1};
GN ORFNames=TSTA_075750 {ECO:0000313|EMBL:EED24203.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED24203.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC family. {ECO:0000256|ARBA:ARBA00007520}.
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DR EMBL; EQ962652; EED24203.1; -; Genomic_DNA.
DR RefSeq; XP_002341590.1; XM_002341549.1.
DR AlphaFoldDB; B8LVS3; -.
DR GeneID; 8099931; -.
DR VEuPathDB; FungiDB:TSTA_075750; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_000960_22_0_1; -.
DR InParanoid; B8LVS3; -.
DR OMA; WGRARTI; -.
DR OrthoDB; 1655250at2759; -.
DR PhylomeDB; B8LVS3; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17502; MFS_Azr1_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23501:SF102; DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED; 1.
DR PANTHER; PTHR23501; MAJOR FACILITATOR SUPERFAMILY; 1.
DR Pfam; PF07690; MFS_1; 1.
DR PRINTS; PR01036; TCRTETB.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 129..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 132..587
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 641 AA; 68427 MW; 369C70118AAE5813 CRC64;
MACWPNGKAS AYGAEDCRFD PCVGHVCGNN EFEGPLYLLF TGHELFGAME CSPLTPRTPK
FLTVQCSMFN SAFHNKGIIN NHGKYSCGER KPLWDEHRTS ITCNTNADSQ PNGDQEPASR
APKLRASRIA VIMLSLGASV FVSALDMTII ATASPEIAGH FQSASGYTWI GSAYTLANTA
TMPTWGKISD IWGRKPLLLA GLVVFFVGSM ICGLADSIGL LLAGRAIQGV GSAALNILVN
ICVSDLFALR DRGLYFGLLS LVWAMASGVG PVLGGVFSEK LSWRWCFYIN LPIIGAVFVL
LLFSLKLNTP RTPMWDGLKA IDWTGGSLVI GSTVMLLLGL DFGGVTRPWS SATVVCLLVF
SVVVGALFVI NEKQIAKYPV IPIELFRYRS GIGSFLLCFC HGLVFMGQGY YMPLYFQAVL
GMGPIMSGVY FLPFILAITF SGALTGLFIQ KTGRYMPTTY LGLALMTLGV GLLINLDEYL
NWSKLITFQI VSGIGIGLNF EAPLLSLQAI VGKHNAATAT STIGFVRAIA CAISIVLGSV
VFQNQMVKQG PSLTAALGPS LGGLLSNGDA AANIGIVNSL PSAQQAAARH ALHHALTTMW
VMYVGFAGAG LIGGCLMSSH PLSREHEAVV LGLRRESDNG N
//
