ID B8MUJ8_TALSN Unreviewed; 1998 AA.
AC B8MUJ8;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Reverse transcriptase, putative {ECO:0000313|EMBL:EED11666.1};
GN ORFNames=TSTA_108520 {ECO:0000313|EMBL:EED11666.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED11666.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
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DR EMBL; EQ962661; EED11666.1; -; Genomic_DNA.
DR RefSeq; XP_002488422.1; XM_002488377.1.
DR GeneID; 8103108; -.
DR VEuPathDB; FungiDB:TSTA_108520; -.
DR eggNOG; KOG1075; Eukaryota.
DR HOGENOM; CLU_233969_0_0_1; -.
DR InParanoid; B8MUJ8; -.
DR OrthoDB; 2169149at2759; -.
DR PhylomeDB; B8MUJ8; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:EED11666.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:EED11666.1};
KW Transferase {ECO:0000313|EMBL:EED11666.1}.
FT DOMAIN 1172..1452
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1664..1801
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 221095 MW; 93FEB0C724F7E197 CRC64;
MESPERPPGA TGDPEIIGPG SGVDSSTPSQ ETSQLPPTTR ALFAGLGDCQ KQSNEPTLSN
SDALQAPRQT GETQQAPGTI LEKRKASRLT IGSRTPITRS GLSAAPKRKI TLTAMRAASA
PAEDSLVMGL IEDLNGHLQE AVHQLSAELT TARNVINTQQ GLITTLNARL ESLETYVNAL
QSRQILPLDP FAATREVAAH GPPPRAASTG GLASTPIQLD AAPESRAINS TAPQPPPRYQ
NPTKATKQAI QPPEGPKKVP GTAAKTTKQP ETTAKPLTKP APTKWAAIAA NNTQSGGWKT
VQYKKQALAP SKALSTTNLK PVSTRSKEER RLIFRRRYPK DAPTALKADI LLALNRALAK
AGFPDFVRAV DSGYAASGAL TVLLERGTRS STLVPVYNDT LLAAVRQTDP AVISVEISEQ
WHRVKVQAVP VDRYMYNDQG LALAQEEIEL GTPYRLKREP TWLKRAKTIQ ASNQRFATIV
ITVGSLEEAR TLINKGIKFG GRHHRVAPYW ESNPESICPR CCGIGHSGFM ACGGRSPKCA
ICAGDHEAIE HSCTVVDCRV GPAKPCKHTV IKCANCKGAH EATSPKCPKA REARQRAIRR
MREQSLQDLI PLDETFAVVP PKPVLTLEER PGQSLEEETS TPEEDELLPE MQLEADIHEG
NSQQPLEPEL KSATEAPQSA VVHTALEVAL QAGAGIACLQ EPPVRGKYQI SHPGFLFYWP
EGPREHARVV TAIRRDLVRE LVVEARTDLA NHPYFMVVDV LEQGRRTRIV NCYDNWLGAR
HTYSGESLLT RRALSDLDWG PILEGRCLIL GDFNAHSPMW NVHIDQRVNA RSLEDLIMRH
DLFINNDPDE PTRPHKLRDS TASLETSTEP RVSIIDLTIS SQALGPLSGW EIESQRLTPS
DHVMIWASWE PPTTASTEPT RKEVTGWQIE ALLGDKKALQ EAKDTWNELA KTQPILTDTT
STEEVEREAE WIERTLTEVL NKHCKQIKLC ARSKRWWNSE IEAERSAYSK ARKAYQAGEI
SEEEHREARK GFYSLIRRAK RECWEGFLQG TSEGSLPDQK RCWTALRYTK PQTQGTTPAL
TDEASGEVIA ATFSEKEEVF RHRAFPQAPN SNMQLQLPER GSAHKLVNEE VVKNALFSQG
LEKAPGTDLL NFRAIRLLWN LDSERVVSLT RQCLRLGIHP RVWKTAKGVL LRKNGKTNYT
LASAYRVISL LKCLGKVIEK LVAELITNFA EAQDLFHDGQ FGGRQQRSAI DAVACLVEEI
HQAWANGKLA AALFMDIEGA FDHVILAKLV EVLREASVDG DLIHWVISFL SDRRVTLVID
GHVGKEVPIS SGLPQGSPVS PILFVLYVHG LSRAIERSVP EVRCLSFVDD QGLVTAASSV
KEACRILEKA AEVAIEWGVA NGVQFDRKKT EAAFFYRRHR RQVAQNVSRA RIRVGGELAT
VKSTVRWLGI LLDNQLTWKS HYNARIKTAR NTIIRLNSLC RANGLPPALV RRIQKATVQA
QLLWGAEIWW QGQKTWAQRI QILINKQARG ITGMFPKTPI GALIREAALE PATVLLDARV
ARYTARLLAL PDTHHTAQIL PVTLRHGDLR AQPGEQPLDD REWASRDNKV LNRLGQRLAK
HLAQRLNRDP SGGIERTEQY ELKSFPGSIR VLDNEEALTE ANQQRAGTTF WSDGSRLDTG
RAGAGVTLQA VPGGPWEHVE VPMGHGHEVF DAELVGVATA LEWALERQPL GPIWVFLDAQ
NAIDRLRSTR PGPGQALVLR AHKAAEKLAL RGQPVTIQWV PGHSGIEGNE QADQAAKRAA
SKQTAPGFEH LSLAHVRRAC TEARRAAVSE WAQINAVQGR HRYGRVYKMP RGWNLDPVAG
KAPKRLASRY YQLKTGHAPI GTYLYRIGRR ESPECQACKE PHETVRHVLF ECRGRRTGRR
TLYQALKKAG VPLPTAAEED PEARLFAEPR ATQGLLQFVA EANLFNDKER TAREAESSDA
WGWDTLEEGG LGVTLEDE
//
