ID B8MVA6_TALSN Unreviewed; 768 AA.
AC B8MVA6;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Reverse transcriptase, putative {ECO:0000313|EMBL:EED11562.1};
GN ORFNames=TSTA_008580 {ECO:0000313|EMBL:EED11562.1};
OS Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS 1006) (Penicillium stipitatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC Talaromyces sect. Talaromyces.
OX NCBI_TaxID=441959 {ECO:0000313|EMBL:EED11562.1, ECO:0000313|Proteomes:UP000001745};
RN [1] {ECO:0000313|Proteomes:UP000001745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006
RC {ECO:0000313|Proteomes:UP000001745};
RX PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT (ATCC10500).";
RL Genome Announc. 3:E0155914-E0155914(2015).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; EQ962662; EED11562.1; -; Genomic_DNA.
DR RefSeq; XP_002488743.1; XM_002488698.1.
DR AlphaFoldDB; B8MVA6; -.
DR STRING; 441959.B8MVA6; -.
DR GeneID; 8103246; -.
DR VEuPathDB; FungiDB:TSTA_008580; -.
DR eggNOG; KOG1075; Eukaryota.
DR HOGENOM; CLU_000680_23_5_1; -.
DR InParanoid; B8MVA6; -.
DR OMA; HFPEITH; -.
DR OrthoDB; 2168427at2759; -.
DR PhylomeDB; B8MVA6; -.
DR Proteomes; UP000001745; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR CDD; cd01650; RT_nLTR_like; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00075; RNase_H; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Nucleotidyltransferase {ECO:0000313|EMBL:EED11562.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001745};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:EED11562.1};
KW Transferase {ECO:0000313|EMBL:EED11562.1}.
FT DOMAIN 1..241
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 439..549
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
SQ SEQUENCE 768 AA; 85320 MW; 25B5C1C1757CF952 CRC64;
MLNTLGKFLE AIIARRISYA MESEGLLPSS HLGGRKGIST DHAIQIILDR IRGAWGRGHA
VVSMLLLDVS GAYDNAHHLR LLHNMKKRRL GHFVSWVTAF LTNRSTKIRI PEGISGQIPT
PTGIPQGSPI SPILYLIYNA DLIEDCANLT NHTTTSGWVD DVALMATGNT ESETIRKLQK
ASEIADQWAV RHVSVFDTKK YQLIHFVNPR STTNPESQPI QLRDNVKIKP KEAVKYLGIW
LDTKLCFDTH RDEAIAKAGT SLEALRGLSG STWGVALGSM RRIYQAIVIP QMLYGAAAWF
QPGLMSQRQI SQTISKFAIT QKRAACLISG ALRTTAAEVL NIELHLMPIR LQLDQLTKAT
AIRIRTGPAF AIPDGLAIDV LMTNSSSADT LPWKLMLGRR ADAYWLPRGP WQGEGRADSH
GSGYQGYIGT SMVIPAFGKQ RTECIGTEGT STVYAAEACG IKFALETALQ IADQNIQTKK
LVIFSDSQAA LRTLMNPRMV SGQTYIYDCI DSLRKCIDED IDVTLRWIPG HEGIPGNEAA
DRAAKRAALI GARRQIVPGD IGNWTILAAA AKRRIRQSTK DAWEKQWDKQ KAGKPTKKLV
TQPSKRTLQY WTFLRKATSS ILIQLRTERI GLAHYLWRIN RREQPYCACG LSGQSVRHIL
MECPLYENER GLMWSRIKGF RRTTDLQALL KEKKAAIAIA QFIIDTRVLD QFREVDPEAV
GTYESTETAA QLEPANDKDT DVGTLRTRID MNMSFGSSDS EPANGDAT
//
