ID B8NGB3_ASPFN Unreviewed; 902 AA.
AC B8NGB3;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Rad4 family protein {ECO:0000313|EMBL:EED50690.1};
GN ORFNames=AFLA_134530 {ECO:0000313|EMBL:EED50690.1}, G4B84_005386
GN {ECO:0000313|EMBL:QMW30051.1};
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952 {ECO:0000313|EMBL:EED50690.1, ECO:0000313|Proteomes:UP000001875};
RN [1] {ECO:0000313|EMBL:EED50690.1, ECO:0000313|Proteomes:UP000001875}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 /
RC SRRC 167 {ECO:0000313|Proteomes:UP000001875}, and NRRL3357
RC {ECO:0000313|EMBL:EED50690.1};
RX PubMed=25883274; DOI=10.1128/genomeA.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2] {ECO:0000313|EMBL:QMW30051.1, ECO:0000313|Proteomes:UP000515286}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL3357 {ECO:0000313|EMBL:QMW30051.1,
RC ECO:0000313|Proteomes:UP000515286};
RA Fountain J.C., Clevenger J.P., Nadon B., Youngblood R.C., Korani W.,
RA Chang P.-K., Starr D., Wang H., Isett B., Johnston H.R., Wiggins R.,
RA Chu Y., Agarwal G., Kemerait R.C., Pandey M.K., Bhatnagar D.,
RA Ozias-Akins P., Varshney R.K., Scheffler B.E., Vaughn J.N., Guo B.;
RT "Two New Chromosome-Level Aspergillus flavus Reference Genomes Reveal a
RT Large Insertion Potentially Contributing to Isolate Stress Tolerance and
RT Aflatoxin Production.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; EQ963478; EED50690.1; -; Genomic_DNA.
DR EMBL; CP059868; QMW30051.1; -; Genomic_DNA.
DR RefSeq; XP_002379466.1; XM_002379425.1.
DR AlphaFoldDB; B8NGB3; -.
DR STRING; 332952.B8NGB3; -.
DR EnsemblFungi; EED50690; EED50690; AFLA_134530.
DR VEuPathDB; FungiDB:AFLA_005801; -.
DR eggNOG; KOG2179; Eukaryota.
DR HOGENOM; CLU_003639_0_2_1; -.
DR OMA; TWPGKTK; -.
DR OrthoDB; 181129at2759; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR Proteomes; UP000515286; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.60.290; Rad4, beta-hairpin domain BHD2; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 522..579
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 581..644
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 651..725
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..73
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..526
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..779
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..844
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 101446 MW; 60F0B8F595A56693 CRC64;
MPPFVPRKRL SSADPPSAKR HNATAAPSVD IAALDDESDS PLSDVPSEAA LQDQDLEDEA
SDESESDDDE VDWEDAMDSK ATTATATTPS MTPAHVQDLE LTLDKNEVHL SDIIDGKKAP
SKIERQIRVL THCLHVQFLL HHNAIRNAWA NDSQVHDILR RKLPEALYKE VKKWKVSSGL
ELPEKPPEET TKKKKWKQRR KSERDWGEGS SRMEPGQPDM SRGDPIITLL KVLAAYWKKQ
FKITAPGLRK RGYRPMSHLE ADISAFNKEE HDPERFGEKV CGIEEFRQAA ERMEGSRDLG
AQLFTALLRA LSIEARLVAS LQPLGFGWTK AETYTPKVKV EAEAQTEIGD TEDADSDDSD
VVQKPVGSRT NPKGYDKDLP VPIYWTEVAS PVTHQIIPVD PLVLPNAVAT TPELQAAFEP
RGAKAEKAKQ VICYVIAYSS DKTAKDVTTR YLRRRTWPGK TKGYRMPVEK IPVPGRRGKF
HEYNWFRVIL RIYERSTKSR TAVDDLEDAN DLVPNQPEKK SAKEGDTLQS LKASTEFVLE
RFLRREEALK PGSQHVRTFV SGKGIKAKEE KIYRRADVLK CLSAESWHKE GRQIKKGEAP
LKRVPIRAVT LLRKREVDEL ERETGEKPKQ GLYAKYQTEY IIPPPIRNGV IPKNDYGNID
CFVPSMVPRG ATHIPWPGTV RICKKLGIDY AEAVTGFEFG SKMAVPVIEG VVIASENEDL
VKDAWRADAA EKREKVRRKA EARILQTWRK FLFGLRIAER VREEYGESSR DHERDAYNPF
TSRKSGQQAP APEPHVREPS EEGDPVDYGG GFLLPGEDDG DDGDLIVERH QPSQPERENE
VAAAAESDDA AVMDMEISDT SSVQELSSSP EIADSEDELP DSEPEYVPPA TRRRTRNATR
KG
//
