ID B8P7G0_POSPM Unreviewed; 787 AA.
AC B8P7G0;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=POSPLDRAFT_100989 {ECO:0000313|EMBL:EED83185.1};
OS Postia placenta (strain ATCC 44394 / Madison 698-R) (Brown rot fungus)
OS (Poria monticola).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Postiaceae; Postia.
OX NCBI_TaxID=561896 {ECO:0000313|Proteomes:UP000001743};
RN [1] {ECO:0000313|EMBL:EED83185.1, ECO:0000313|Proteomes:UP000001743}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 44394 / Madison 698-R {ECO:0000313|Proteomes:UP000001743};
RX PubMed=19193860; DOI=10.1073/pnas.0809575106;
RA Martinez D., Challacombe J., Morgenstern I., Hibbett D., Schmoll M.,
RA Kubicek C.P., Ferreira P., Ruiz-Duenas F.J., Martinez A.T., Kersten P.,
RA Hammel K.E., Vanden Wymelenberg A., Gaskell J., Lindquist E., Sabat G.,
RA Splinter BonDurant S., Larrondo L.F., Canessa P., Vicuna R., Yadav J.,
RA Doddapaneni H., Subramanian V., Pisabarro A.G., Lavin J.L., Oguiza J.A.,
RA Master E., Henrissat B., Coutinho P.M., Harris P., Magnuson J.K.,
RA Baker S.E., Bruno K., Kenealy W., Hoegger P.J., Kuees U., Ramaiya P.,
RA Lucas S., Salamov A., Shapiro H., Tu H., Chee C.L., Misra M., Xie G.,
RA Teter S., Yaver D., James T., Mokrejs M., Pospisek M., Grigoriev I.V.,
RA Brettin T., Rokhsar D., Berka R., Cullen D.;
RT "Genome, transcriptome, and secretome analysis of wood decay fungus Postia
RT placenta supports unique mechanisms of lignocellulose conversion.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:1954-1959(2009).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; EQ966272; EED83185.1; -; Genomic_DNA.
DR RefSeq; XP_002471632.1; XM_002471587.1.
DR AlphaFoldDB; B8P7G0; -.
DR STRING; 561896.B8P7G0; -.
DR KEGG; ppl:POSPLDRAFT_100989; -.
DR HOGENOM; CLU_005943_1_0_1; -.
DR InParanoid; B8P7G0; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000001743; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000001743};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 20..216
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 264..721
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 787 AA; 85493 MW; 4DCA3EB3B29E3A31 CRC64;
MVLTCVSEIA NGSTSLLDLV KALGEYLTAE EDDLRSKGVD FLSLVIGKCP PEKFNRQSVR
VLVTFYCGKL EDTETIIPAL RGLVPLMSLS PVTSTDAVEV TKAVIKHVKM KALVQSQRYL
VFKTIDTLIA NQRDALKAMG KEFISGYISL AEGEKDPRNL LLAFAIDRVM VLEFDISAHV
EDLFNVTFCY FPITFRPPPD DPYGITTDDL KNALREPALG LLVTIAEFAP SHVTQTTLPL
LFVSLPDRAP PRDAQAERIR CWRTLDSLSR LCKQADLFET LVVRLLTKLD LVCVPPADGA
LAQDETDIEP RAAYAHSILR TMADVLAAKV AAGHTDVTKY ADRLVPRIFN LFIYAALVSN
GRYMAATDPR LVSVASQIVT LVVQTLSPQR QEAFVSVLFA GYLHGDAGKL AEGHQKLPAD
KKFEPFSPEV SSLQKNLLAL FSAAIIALHK EVALPVPDED AFLNTLLQWS SAHAENILQR
DAATHAISSL VNRRPGGLGV FLAETLDSFW TTQIADRVTP PPKRKEGISS WAWITKALLI
RNDAAAARNI DKLLGLLDDA EVSWDAARAI GSVVATDKIL TKRNHAVIKA GCSLRLALVA
SLTGVAQILY AQRYCNSVLP RIVEGAKSSS DSQKQNAFLV ALTSLIQSVP KSVYAPQMST
LMPLLLRGLD LPDTEIRAGV MDTLFAAAQS DANENGVVAE HAASLVSMML RNSMVKEMPA
AASGRNQVSR LCNYKRVGPP IYDTNLYDGG DLGSVGVCVE GVYDNLLMSS GGGGHHGEGY
GHILFTS
//
