ID B8QIF4_9SAUR Unreviewed; 151 AA.
AC B8QIF4;
DT 03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 03-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Neurotrophin-3 {ECO:0000256|ARBA:ARBA00018014, ECO:0000256|RuleBase:RU365037};
DE Short=NT-3 {ECO:0000256|RuleBase:RU365037};
DE Flags: Fragment;
GN Name=NT3 {ECO:0000313|EMBL:ACB37527.1};
OS Zonosaurus laticaudatus (Western girdled lizard).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Scinciformata; Cordyloidea;
OC Gerrhosauridae; Zonosaurus.
OX NCBI_TaxID=219626 {ECO:0000313|EMBL:ACB37527.1};
RN [1] {ECO:0000313|EMBL:ACB37527.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=APR1283 {ECO:0000313|EMBL:ACB37527.1};
RA Noonan B.P., Rasiliamanana A., Karanth P., Gauthier J., Yoder A.D.;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACB37527.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=APR1283 {ECO:0000313|EMBL:ACB37527.1};
RX PubMed=18952185; DOI=10.1016/j.ympev.2008.10.004;
RA Raselimanana A.P., Noonan B., Karanth K.P., Gauthier J., Yoder A.D.;
RT "Phylogeny and evolution of Malagasy plated lizards.";
RL Mol. Phylogenet. Evol. 50:336-344(2009).
CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive
CC sensory neurons. {ECO:0000256|ARBA:ARBA00003312,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU365037}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU365037}.
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DR EMBL; EU571601; ACB37527.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005165; F:neurotrophin receptor binding; IEA:InterPro.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR015578; Neurotrophin-3.
DR InterPro; IPR045815; NTF3_N.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1.
DR Pfam; PF00243; NGF; 1.
DR Pfam; PF19338; NTF3_N; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01914; NEUROTROPHN3.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU365037};
KW Growth factor {ECO:0000256|RuleBase:RU365037};
KW Secreted {ECO:0000256|RuleBase:RU365037};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..110
FT /note="Neutrophin-3 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19338"
FT DOMAIN 121..151
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|Pfam:PF00243"
FT UNSURE 10
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:ACB37527.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACB37527.1"
FT NON_TER 151
FT /evidence="ECO:0000313|EMBL:ACB37527.1"
SQ SEQUENCE 151 AA; 17220 MW; 61370060498345C5 CRC64;
SLPEDSINSX IIKLIQADIL KNKVSKQMVD IKDSIQDTMK KAEAVEPDVD GDENVKLDFQ
PVISMETELL RQQRRYSSPR VLLSDNTALE PPPLYLMEDY IGNSVVVNRT SRRKRFAENK
SHRGEYSVCD SESRWVTDKS SAIDIRGHQV T
//
