ID   B8X2D6_LISMN            Unreviewed;       742 AA.
AC   B8X2D6;
DT   03-MAR-2009, integrated into UniProtKB/TrEMBL.
DT   03-MAR-2009, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Internalin A {ECO:0000313|EMBL:ACL37786.1};
DE   Flags: Fragment;
GN   Name=inlA {ECO:0000313|EMBL:ACL37786.1};
OS   Listeria monocytogenes.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=1639 {ECO:0000313|EMBL:ACL37786.1};
RN   [1] {ECO:0000313|EMBL:ACL37786.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NRRL_B-33360 {ECO:0000313|EMBL:ACL37786.1};
RX   PubMed=18931295; DOI=10.1128/AEM.01127-08;
RA   Ward T.J., Ducey T.F., Usgaard T., Dunn K.A., Bielawski J.P.;
RT   "Multilocus genotyping assays for single nucleotide polymorphism-based
RT   subtyping of Listeria monocytogenes isolates.";
RL   Appl. Environ. Microbiol. 74:7629-7642(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the internalin family.
CC       {ECO:0000256|ARBA:ARBA00009432}.
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DR   EMBL; FJ024984; ACL37786.1; -; Genomic_DNA.
DR   AlphaFoldDB; B8X2D6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1220; -; 1.
DR   Gene3D; 2.60.40.4270; Listeria-Bacteroides repeat domain; 3.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR012569; Inl_IR.
DR   InterPro; IPR047600; InlA.
DR   InterPro; IPR013378; InlB-like_B-rpt.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   NCBIfam; NF033189; internalin_A; 1.
DR   NCBIfam; TIGR02543; List_Bact_rpt; 3.
DR   NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR   PANTHER; PTHR46652; LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46652:SF3; LEUCINE-RICH REPEAT-CONTAINING PROTEIN 9 ISOFORM X1; 1.
DR   Pfam; PF09479; Flg_new; 3.
DR   Pfam; PF00746; Gram_pos_anchor; 1.
DR   Pfam; PF12799; LRR_4; 6.
DR   Pfam; PF08191; LRR_adjacent; 1.
DR   SMART; SM00365; LRR_SD22; 15.
DR   SMART; SM00369; LRR_TYP; 11.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR   PROSITE; PS51450; LRR; 13.
PE   3: Inferred from homology;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        718..735
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          709..742
FT                   /note="Gram-positive cocci surface proteins LPxTG"
FT                   /evidence="ECO:0000259|PROSITE:PS50847"
FT   REGION          647..699
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ACL37786.1"
SQ   SEQUENCE   742 AA;  80079 MW;  6A6E964B9244144F CRC64;
     TVLGKTNVTD TVSQTDLDQV TTLQADRLGI KSIDGLEYLN NLTQINFSNN QLTDITPLKD
     LTKLVDILMN NNQIADITPL ANLSNLTGLT LFNNQITDID PLKNLTNLNR LELSSNTISD
     ISALSGLTNL QQLSFGNQVT DLKPLANLTT LERLDISSNK VSDISVLAKL TNLESLIATN
     NQISDITPLG ILTNLDELSL NGNQLKDIGT LASLTNLTDL DLANNQISNL APLSGLTKLT
     ELKLGANQIS NISPLAGLTA LTNLELNENQ LEDISPISNL KNLTYLTLYF NNISDISPVS
     SLTKLQRLFF YNNKVSDVSS LASLTNINWL SAGHNQISDL TPLANLTRIT QLGLNDQAWT
     NAPVNYKANV SIPNTVKNVT GALIAPATIS DGGSYAEPDI TWNLPSYTNE VSYTFNQSVT
     IGKGTTTFSG TVTQPLKAIF NAKFHVDGKE TTKEVEAGNL LTEPAKPVKE GYTFVGWFDA
     QTGGTKWNFS TDKMPTNDID LYAQFSINSY TATFDNDGVT TSQTVDYQGL LQEPTAPTKE
     GYTFKGWYDA KTGGDKWDFA TSKMPAKNIT LYAQYSANSY TVTFDVDGKT TTQAVDYQGL
     LKEPKTPTKA GYTFKGWYDE KTDGKKWDFA TDKMPANDIT LFAQFTKNPV APPTTGGNTP
     PTTNNGGNTT PPSANIPGSN TTNTSTGNSA STTSTMNAYD PYNSKEASLP TTGDSDNALY
     LLIGLLAVGT AVALTKKARA SK
//