ID B9A5A8_ADE08 Unreviewed; 495 AA.
AC B9A5A8;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=E1B 55 kDa protein {ECO:0000256|ARBA:ARBA00022118};
DE AltName: Full=E1B protein, large T-antigen {ECO:0000256|ARBA:ARBA00030428};
DE AltName: Full=E1B-495R {ECO:0000256|ARBA:ARBA00031863};
GN Name=E1B {ECO:0000313|EMBL:BAH18772.1};
OS Human adenovirus D serotype 8 (HAdV-8) (Human adenovirus 8).
OC Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus D.
OX NCBI_TaxID=31545 {ECO:0000313|EMBL:BAH18772.1, ECO:0000313|Proteomes:UP000111745};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|Proteomes:UP000103676, ECO:0000313|Proteomes:UP000111745}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=8e {ECO:0000313|EMBL:BAH18844.1}, and Trim
RC {ECO:0000313|EMBL:BAH18772.1};
RX PubMed=19264666; DOI=10.1099/vir.0.009225-0;
RA Kaneko H., Iida T., Ishiko H., Ohguchi T., Ariga T., Tagawa Y., Aoki K.,
RA Ohno S., Suzutani T.;
RT "Analysis of the complete genome sequence of epidemic keratoconjunctivitis-
RT related human adenovirus type 8, 19, 37 and a novel serotype.";
RL J. Gen. Virol. 90:1471-1476(2009).
RN [2] {ECO:0000313|EMBL:BAM66708.1, ECO:0000313|Proteomes:UP000118238}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Trim variant {ECO:0000313|EMBL:BAM66708.1};
RA Yamane S., Lee A.W.L., Hanaoka N., Gonzalez G., Kaneko H., Ishida S.,
RA Kitaichi N., Ohno S., Koyanagi K.O., Aoki K., Fujimoto T., Yawata N.,
RA Watanabe H.;
RT "Identification of Contamination in the American Type Culture Collection
RT Stock of Human Adenovirus Type 8 by Whole-Genome Sequencing.";
RL J. Virol. 85:1285-1286(2012).
RN [3] {ECO:0000313|EMBL:BBE38461.1, ECO:0000313|Proteomes:UP000594886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Singapore {ECO:0000313|EMBL:BBE38461.1,
RC ECO:0000313|Proteomes:UP000594886};
RA Gonzalez G., Aoki K., Koyanagi K.O., Watanabe H.;
RT "Evolution of Human Adenovirus Species D type 8 in Japan for the last 50
RT years.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:BAU22118.1, ECO:0000313|Proteomes:UP000154937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S9 {ECO:0000313|EMBL:BAU22118.1};
RA Okuyama Y., Yamane S., Panto L., Gonzalez G., Koyanagi O.K., Kaneko H.,
RA Aoki K., Watanabe H.;
RT "The genome sequence of human adenovirus type 8.";
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000097804, ECO:0000313|Proteomes:UP000106216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NYS05_2088 {ECO:0000313|EMBL:ANW61297.1}, NYS05_2091
RC {ECO:0000313|EMBL:ANW60738.1}, NYS12_13421
RC {ECO:0000313|EMBL:ANW61262.1}, NYS12_4716
RC {ECO:0000313|EMBL:ANW60773.1}, NYS12_4717
RC {ECO:0000313|EMBL:ANW60808.1}, NYS12_4718
RC {ECO:0000313|EMBL:ANW60843.1}, NYS12_4719
RC {ECO:0000313|EMBL:ANW60877.1}, NYS12_4720
RC {ECO:0000313|EMBL:ANW60912.1}, NYS12_4721
RC {ECO:0000313|EMBL:ANW60947.1}, NYS12_5493
RC {ECO:0000313|EMBL:ANW60982.1}, NYS12_5670
RC {ECO:0000313|EMBL:ANW61017.1}, NYS12_5671
RC {ECO:0000313|EMBL:ANW61052.1}, NYS12_5673
RC {ECO:0000313|EMBL:ANW61087.1}, NYS12_5676
RC {ECO:0000313|EMBL:ANW61122.1}, NYS12_5678
RC {ECO:0000313|EMBL:ANW61157.1}, NYS12_5792
RC {ECO:0000313|EMBL:ANW61192.1}, and NYS12_6095
RC {ECO:0000313|EMBL:ANW61227.1};
RA Lamson D.M., Shudt M.D., StGeorge K., Kajon A.E.;
RT "Molecular typing and Whole Genome Next Generation Sequencing of Human
RT Adenovirus 8 strains recovered from four 2012 Outbreaks of
RT Keratoconjunctivitis in New York State.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|Proteomes:UP000315233, ECO:0000313|Proteomes:UP000317527}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ger/Berlin/04_2003 {ECO:0000313|EMBL:AOX15340.1,
RC ECO:0000313|Proteomes:UP000315233}, Ger/Bottrop/06_2012
RC {ECO:0000313|EMBL:AKR79849.1, ECO:0000313|Proteomes:UP000315818},
RC Ger/Celle/03_2012 {ECO:0000313|EMBL:AKR79812.1,
RC ECO:0000313|Proteomes:UP000317902}, Ger/Celle/06_2010
RC {ECO:0000313|Proteomes:UP000316837,
RC ECO:0000313|Proteomes:UP000317258}, Ger/Hannover/07_2010
RC {ECO:0000313|EMBL:AKR79590.1, ECO:0000313|Proteomes:UP000317996},
RC Ger/Hannover/08_2012 {ECO:0000313|EMBL:AKR79775.1,
RC ECO:0000313|Proteomes:UP000318849}, Ger/Krefeld/11_2005
RC {ECO:0000313|EMBL:AOX15451.1, ECO:0000313|Proteomes:UP000317527},
RC Ger/Neubrandenburg/08_2006 {ECO:0000313|EMBL:AOX15377.1,
RC ECO:0000313|Proteomes:UP000317772}, and Ger/Teltow/09_2012
RC {ECO:0000313|EMBL:AKR79923.1, ECO:0000313|Proteomes:UP000320350};
RA Hage E., Espelage W., Panto L., Lamson D.M., Ganzenmueller T., Heim A.;
RT "Phylogenetic analysis of the German 2012/2013 adenovirus type 8 epidemic
RT by next generation sequencing.";
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAX64850.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Case90_20131544 {ECO:0000313|EMBL:BAX64850.1};
RA Iida M., Okuyama Y., Koyanagi K., Hashimoto S., Toda J., Osako H.,
RA Hinokuma R., Aoki K., Watanabe H.;
RT "Genome of Human Mastadenovirus causing EKC.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:BBC08477.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Fukuoka_2_2014 {ECO:0000313|EMBL:BBC08477.1}, and
RC Fukuoka_5_2014 {ECO:0000313|EMBL:BBC08511.1};
RC TISSUE=Ocular {ECO:0000313|EMBL:BBC08477.1};
RA Tsukahara-Kawamura T., Fujimoto T., Gonzalez G., Hanaoka N., Konagaya M.,
RA Arashiro T., Saeki Y., Uchio E.;
RT "Epidemic keratoconjunctivitis cases resulting from adenovirus type 8 and
RT 54 detected at Fukuoka University Hospital between 2014 and 2015.";
RL Jpn. J. Infect. Dis. 0:0-0(2018).
RN [9] {ECO:0000313|EMBL:QJA41501.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VN2017 {ECO:0000313|EMBL:QJA41501.1};
RA Nguyen H.T.T., Le A.T., Nguyen H.V., Nguyen U.T., Nguyen T.P., Tran A.T.T.,
RA Nguyen H.Q., Hoang T.A., Hoang H.T.M., Le S.T., Nguyen S.V.;
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:QJA41501.1, ECO:0000313|Proteomes:UP000500937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VN2017 {ECO:0000313|EMBL:QJA41501.1};
RX PubMed=32266999;
RA Nguyen T.T.H., Le T.A., Nguyen V.H., Nguyen T.U., Nguyen P.T.,
RA Anh Tran T.T., Nguyen Q.H., Hoang A.T., Hoang M.H., Le T.S., Nguyen V.S.;
RT "Molecular typing of conjunctivitis-causing adenoviruses in Hanoi, Vietnam
RT from 2017 to 2019 and complete genome analysis of the most prevalent type
RT (HAdV-8).";
RL J. Med. Virol. 0:0-0(2020).
CC -!- FUNCTION: Plays a major role to prevent cellular inhibition of viral
CC genome replication. Assembles an SCF-like E3 ubiquitin ligase complex
CC based on the cellular proteins ELOB, ELOC, CUL5 and RBX1, in
CC cooperation with viral E4orf6. This viral RING-type ligase
CC ubiquitinates cellular substrates and targets them to proteasomal
CC degradation: TP53/p53, LIG4, MRE11-RAD50-NBS1 (MRN) complex, ITGA3,
CC DAXX and BLM. Degradation of host TP53/p53 activity is essential for
CC preventing E1A-induced TP53 accumulation that would otherwise lead to
CC cell apoptosis and growth arrest. E1B-55K also inactivates TP53
CC transcription-factor activity by binding its transactivation domain.
CC E1B-55K also functions as a SUMO1 E3 ligase for TP53 which causes the
CC latter to be sequestered in promyelocytic leukemia (PML) nuclear bodies
CC thereby contributing to maximal inhibition of TP53 function.
CC {ECO:0000256|ARBA:ARBA00002808}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Host nucleus
CC {ECO:0000256|ARBA:ARBA00004147}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the adenoviridae E1B 55 kDa protein family.
CC {ECO:0000256|ARBA:ARBA00008605}.
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DR EMBL; KP016719; AKR79516.1; -; Genomic_DNA.
DR EMBL; KP016720; AKR79553.1; -; Genomic_DNA.
DR EMBL; KP016721; AKR79590.1; -; Genomic_DNA.
DR EMBL; KP016726; AKR79775.1; -; Genomic_DNA.
DR EMBL; KP016727; AKR79812.1; -; Genomic_DNA.
DR EMBL; KP016728; AKR79849.1; -; Genomic_DNA.
DR EMBL; KP016730; AKR79923.1; -; Genomic_DNA.
DR EMBL; KT340055; ANW60738.1; -; Genomic_DNA.
DR EMBL; KT340056; ANW60773.1; -; Genomic_DNA.
DR EMBL; KT340057; ANW60808.1; -; Genomic_DNA.
DR EMBL; KT340058; ANW60843.1; -; Genomic_DNA.
DR EMBL; KT340059; ANW60877.1; -; Genomic_DNA.
DR EMBL; KT340060; ANW60912.1; -; Genomic_DNA.
DR EMBL; KT340061; ANW60947.1; -; Genomic_DNA.
DR EMBL; KT340062; ANW60982.1; -; Genomic_DNA.
DR EMBL; KT340063; ANW61017.1; -; Genomic_DNA.
DR EMBL; KT340064; ANW61052.1; -; Genomic_DNA.
DR EMBL; KT340065; ANW61087.1; -; Genomic_DNA.
DR EMBL; KT340066; ANW61122.1; -; Genomic_DNA.
DR EMBL; KT340067; ANW61157.1; -; Genomic_DNA.
DR EMBL; KT340068; ANW61192.1; -; Genomic_DNA.
DR EMBL; KT340069; ANW61227.1; -; Genomic_DNA.
DR EMBL; KT340070; ANW61262.1; -; Genomic_DNA.
DR EMBL; KT340071; ANW61297.1; -; Genomic_DNA.
DR EMBL; KT862545; AOX15340.1; -; Genomic_DNA.
DR EMBL; KT862546; AOX15377.1; -; Genomic_DNA.
DR EMBL; KT862548; AOX15451.1; -; Genomic_DNA.
DR EMBL; AB448767; BAH18772.1; -; Genomic_DNA.
DR EMBL; AB448769; BAH18844.1; -; Genomic_DNA.
DR EMBL; AB746853; BAM66708.1; -; Genomic_DNA.
DR EMBL; AB897885; BAU22118.1; -; Genomic_DNA.
DR EMBL; LC215432; BAX64850.1; -; Genomic_DNA.
DR EMBL; LC312461; BBC08477.1; -; Genomic_DNA.
DR EMBL; LC312462; BBC08511.1; -; Genomic_DNA.
DR EMBL; AB701748; BBE38461.1; -; Genomic_DNA.
DR EMBL; MN431241; QJA41501.1; -; Genomic_DNA.
DR Proteomes; UP000097804; Genome.
DR Proteomes; UP000103676; Genome.
DR Proteomes; UP000106216; Genome.
DR Proteomes; UP000106501; Genome.
DR Proteomes; UP000107236; Genome.
DR Proteomes; UP000108850; Genome.
DR Proteomes; UP000109922; Genome.
DR Proteomes; UP000111097; Genome.
DR Proteomes; UP000111611; Genome.
DR Proteomes; UP000111745; Genome.
DR Proteomes; UP000116185; Genome.
DR Proteomes; UP000118238; Genome.
DR Proteomes; UP000121074; Genome.
DR Proteomes; UP000128375; Genome.
DR Proteomes; UP000137783; Genome.
DR Proteomes; UP000146925; Genome.
DR Proteomes; UP000147346; Genome.
DR Proteomes; UP000154570; Genome.
DR Proteomes; UP000154646; Genome.
DR Proteomes; UP000154937; Genome.
DR Proteomes; UP000163799; Genome.
DR Proteomes; UP000315233; Genome.
DR Proteomes; UP000315818; Genome.
DR Proteomes; UP000315910; Genome.
DR Proteomes; UP000316837; Genome.
DR Proteomes; UP000317258; Genome.
DR Proteomes; UP000317527; Genome.
DR Proteomes; UP000317772; Genome.
DR Proteomes; UP000317899; Genome.
DR Proteomes; UP000317902; Genome.
DR Proteomes; UP000317996; Genome.
DR Proteomes; UP000318166; Genome.
DR Proteomes; UP000318849; Genome.
DR Proteomes; UP000320350; Genome.
DR Proteomes; UP000500937; Genome.
DR Proteomes; UP000594886; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR InterPro; IPR006717; Adeno_E1B_55K_N.
DR InterPro; IPR002612; Adeno_E1B_55kDa.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR Pfam; PF01696; Adeno_E1B_55K; 1.
DR Pfam; PF04623; Adeno_E1B_55K_N; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
PE 3: Inferred from homology;
KW Early protein {ECO:0000256|ARBA:ARBA00022518};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323}.
FT DOMAIN 1..69
FT /note="Adenovirus E1B protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04623"
FT REGION 40..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55091 MW; E2C6B7C757133234 CRC64;
MEPGHPTKQG LHSGLCSHAP VEGLDEAAGT ENLELLASTA SSFGSSSSTQ TNIHVGGRNE
GGHGQEPEER PGPSVGRGAG LNEVSSLYPE LSKVLTSMAR GVKRERSDGG NTGLMTQLTA
SLMNRKRPER ITWHELQQEC RDEIGLMQDK YGLEQIKTHW LNPDEDWEEA IKKYAKIALR
PDCKYRVTKT VNIKHACYIS GNGAEVDIDT LDKSAFRCCM MGMRAGVMNM NSMIFINIKF
NGEKFNGVLF MANSHMTLHG CSFFGFNNMC AEVWGAAKIR GCKFYGCWMG VVGRPKSEMS
VKQCVFEKCY LGVCTEGNAR VRHCSSLETG CFCLVKGTAS IKHNVVKGCT DERMYNMLTC
DSGVCHILKN IHVTSHPRKK WPVFENNLLI KCHMHLGARR GTFQPYQCNF SQTKLLLEND
AFSRVNLNGI FDMDVSVYKI LRYDETKSRV RACECGGRHT RMQPVALDVT EELRPDHLVM
ACTGTEFSSS GEDTD
//
