ID B9A837_PONAB Unreviewed; 388 AA.
AC B9A837; H2ND88;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=pepsin A {ECO:0000256|ARBA:ARBA00011924};
DE EC=3.4.23.1 {ECO:0000256|ARBA:ARBA00011924};
GN Name=pg {ECO:0000313|EMBL:BAH20538.1};
GN Synonyms=LOC100454826 {ECO:0000313|Ensembl:ENSPPYP00000003685.2}, PG
GN {ECO:0000313|Ensembl:ENSPPYP00000025639.1};
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601 {ECO:0000313|EMBL:BAH20538.1};
RN [1] {ECO:0000313|Ensembl:ENSPPYP00000003685.2, ECO:0000313|Proteomes:UP000001595}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Wilson R.K., Mardis E.;
RT "A 6x draft sequence assembly of the Pongo pygmaeus abelii genome.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAH20538.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Gastric mucosa {ECO:0000313|EMBL:BAH20538.1};
RX PubMed=20349055; DOI=10.1007/s00239-010-9320-8;
RA Narita Y., Oda S., Takenaka O., Kageyama T.;
RT "Lineage-specific duplication and loss of pepsinogen genes in hominoid
RT evolution.";
RL J. Mol. Evol. 70:313-324(2010).
RN [3] {ECO:0000313|Ensembl:ENSPPYP00000003685.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Shows particularly broad specificity; although bonds
CC involving phenylalanine and leucine are preferred, many others are also
CC cleaved to some extent. {ECO:0000256|ARBA:ARBA00002318}.
CC -!- SIMILARITY: Belongs to the peptidase A1 family.
CC {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR EMBL; AB458301; BAH20538.1; -; mRNA.
DR RefSeq; NP_001138942.1; NM_001145470.1.
DR MEROPS; A01.001; -.
DR Ensembl; ENSPPYT00000003817.2; ENSPPYP00000003685.2; ENSPPYG00000003195.2.
DR Ensembl; ENSPPYT00000036180.1; ENSPPYP00000025639.1; ENSPPYG00000030830.1.
DR GeneID; 100271705; -.
DR KEGG; pon:100271705; -.
DR eggNOG; KOG1339; Eukaryota.
DR GeneTree; ENSGT00940000155036; -.
DR HOGENOM; CLU_013253_3_0_1; -.
DR OMA; INNINAW; -.
DR OrthoDB; 1120702at2759; -.
DR TreeFam; TF314990; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd05478; pepsin_A; 1.
DR Gene3D; 6.10.140.60; -; 1.
DR Gene3D; 2.40.70.10; Acid Proteases; 2.
DR InterPro; IPR001461; Aspartic_peptidase_A1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR012848; Aspartic_peptidase_N.
DR InterPro; IPR034162; Pepsin_A.
DR InterPro; IPR033121; PEPTIDASE_A1.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR47966:SF22; PEPSIN A-3-RELATED; 1.
DR Pfam; PF07966; A1_Propeptide; 1.
DR Pfam; PF00026; Asp; 1.
DR PRINTS; PR00792; PEPSIN.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 2.
DR PROSITE; PS51767; PEPTIDASE_A1; 1.
PE 2: Evidence at transcript level;
KW Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW Digestion {ECO:0000256|ARBA:ARBA00022757};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601461-2};
KW Hydrolase {ECO:0000256|RuleBase:RU000454, ECO:0000313|EMBL:BAH20538.1};
KW Protease {ECO:0000256|RuleBase:RU000454};
KW Reference proteome {ECO:0000313|Proteomes:UP000001595};
KW Signal {ECO:0000256|SAM:SignalP}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..388
FT /note="pepsin A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041198426"
FT DOMAIN 76..385
FT /note="Peptidase A1"
FT /evidence="ECO:0000259|PROSITE:PS51767"
FT ACT_SITE 94
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT ACT_SITE 277
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT DISULFID 107..112
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT DISULFID 268..272
FT /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ SEQUENCE 388 AA; 41828 MW; F4560558A5CE27A8 CRC64;
MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA SKYFPQGKAP
TLLHEQPLEN YLDVEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCYSL ACMDHNLFNP
QDSSTYKSTS ETVSITYGTG SMTGILGYDT VKVGGISDTN QIFGLSESEP GSFLFFAPFD
GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DKSGSVVIFG GIDSSYYTGS
LNWVPVTVEG YWQITVDSIT MNGKTIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS
ENSDGDMVVS CSAISSLPDI VFTINGVQYP LPPSAYILKS EGSCISGFQG MNVPTESGEL
WILGDVFIRQ YFTVFDRANN QVGLAPVA
//
