ID B9AFI5_METSM Unreviewed; 380 AA.
AC B9AFI5;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Peptidase, M48 family {ECO:0000313|EMBL:EEE42225.1};
DE EC=3.4.24.- {ECO:0000313|EMBL:EEE42225.1};
GN ORFNames=METSMIALI_01134 {ECO:0000313|EMBL:EEE42225.1};
OS Methanobrevibacter smithii DSM 2375.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobrevibacter.
OX NCBI_TaxID=483214 {ECO:0000313|EMBL:EEE42225.1, ECO:0000313|Proteomes:UP000003489};
RN [1] {ECO:0000313|EMBL:EEE42225.1, ECO:0000313|Proteomes:UP000003489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2375 {ECO:0000313|EMBL:EEE42225.1,
RC ECO:0000313|Proteomes:UP000003489};
RA Fulton L., Clifton S., Fulton B., Xu J., Minx P., Pepin K.H., Johnson M.,
RA Bhonagiri V., Nash W.E., Mardis E.R., Wilson R.K.;
RL Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEE42225.1, ECO:0000313|Proteomes:UP000003489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 2375 {ECO:0000313|EMBL:EEE42225.1,
RC ECO:0000313|Proteomes:UP000003489};
RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D.,
RA Gordon J.;
RT "Draft genome sequence of Methanobrevibacter smithii (DSM 2375).";
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003983};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU003983};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}.
CC -!- SIMILARITY: Belongs to the peptidase M48 family.
CC {ECO:0000256|RuleBase:RU003983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEE42225.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABYW01000010; EEE42225.1; -; Genomic_DNA.
DR RefSeq; WP_004036035.1; NZ_DS996911.1.
DR AlphaFoldDB; B9AFI5; -.
DR PATRIC; fig|483214.13.peg.1086; -.
DR HOGENOM; CLU_726869_0_0_2; -.
DR OrthoDB; 11143at2157; -.
DR Proteomes; UP000003489; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07331; M48C_Oma1_like; 1.
DR Gene3D; 3.30.2010.10; Metalloproteases ('zincins'), catalytic domain; 1.
DR InterPro; IPR025874; DZR.
DR InterPro; IPR001915; Peptidase_M48.
DR PANTHER; PTHR22726; METALLOENDOPEPTIDASE OMA1; 1.
DR PANTHER; PTHR22726:SF1; METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL; 1.
DR Pfam; PF12773; DZR; 1.
DR Pfam; PF01435; Peptidase_M48; 1.
DR Pfam; PF13248; zf-ribbon_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003983};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003983};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003983};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003983};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 61..250
FT /note="Peptidase M48"
FT /evidence="ECO:0000259|Pfam:PF01435"
FT DOMAIN 332..377
FT /note="DZANK-type"
FT /evidence="ECO:0000259|Pfam:PF12773"
SQ SEQUENCE 380 AA; 42373 MW; 1765D90739C9651C CRC64;
MSKDDRSGLN PFTGKSHYDN IDDDKFLNEC YNEYYNKIDG HEILDQTQEG QLILKVTSNL
ITAVEDYLAK IGRSDYTADY YDWEVHLIAD EDENAMCIPG GKIIVLSGIL PIANTEEKIA
FILGHEMAHA LLDHSRTQSS VRNTKNTITT LSRIGSLGLI LLGEEELGLA TSAITNIADI
GSELFLIQPF GRSQEIEADK LGMMIIHWAG YDIRRIPAFW QSMSEENANN FDFFSTHPSD
DKRIAAMNEM IFEIENRTDF YSQPVLSDST STSSNILEKV PTFETPSAGV SGIAATKNSH
SANTCKYCGN IVKIDDIFCT NCGKKIKTEL RCNKCGHPVN DDDIFCTNCG NKLNHEWKCS
NCGSTVNKDD TFCFNCGNKI
//
