ID B9BE97_9BURK Unreviewed; 506 AA.
AC B9BE97;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN Name=mmsA {ECO:0000313|EMBL:EED97649.1};
GN ORFNames=BURMUCGD1_1937 {ECO:0000313|EMBL:EED97649.1};
OS Burkholderia multivorans CGD1.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=513051 {ECO:0000313|EMBL:EED97649.1, ECO:0000313|Proteomes:UP000005493};
RN [1] {ECO:0000313|EMBL:EED97649.1, ECO:0000313|Proteomes:UP000005493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CGD1 {ECO:0000313|EMBL:EED97649.1,
RC ECO:0000313|Proteomes:UP000005493};
RX PubMed=23105085; DOI=10.1128/JB.01306-12;
RA Varga J.J., Losada L., Zelazny A.M., Brinkac L., Harkins D., Radune D.,
RA Hostetler J., Sampaio E.P., Ronning C.M., Nierman W.C., Greenberg D.E.,
RA Holland S.M., Goldberg J.B.;
RT "Draft Genome Sequence Determination for Cystic Fibrosis and Chronic
RT Granulomatous Disease Burkholderia multivorans Isolates.";
RL J. Bacteriol. 194:6356-6357(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EED97649.1}.
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DR EMBL; ACFB01000014; EED97649.1; -; Genomic_DNA.
DR RefSeq; WP_006402124.1; NZ_ACFB01000014.1.
DR AlphaFoldDB; B9BE97; -.
DR Proteomes; UP000005493; Unassembled WGS sequence.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:UniProtKB-EC.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EED97649.1}.
FT DOMAIN 26..486
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 506 AA; 54128 MW; E0344367DC18BEE2 CRC64;
MNPVPAYTSD ADVGHYLDGA PVAGRSGRFQ DVFNPALGRA VRRVALADDG EVQRAVASAA
AAFPDWAATP PIRRARVLHR FLQLMNEHRD ALAAIITAEH GKVFSDAQGE VARGIDIVEF
ACGIPQLLKG DYTDQVSTGI DNWTMRQPLG VVAGITPFNF PCMVPCWMFP VAIATGNTFV
LKPSERDPSA ALYIADLLTQ AGLPPGVFNV VQGDKGAVDA LLDHPDVQAV SFVGSTPIAA
YVQQRAVQSG KRVQALGGAK NHLVVMPDAN LEQAVDALIG AAYGSAGERC MAISVAVLVG
DVAERIVPAV AERARKLVIG DGMSPEVEMG PIITGEALKR IESYIELGVQ EGAQLVVDGR
GLRVPGREQG FFTGGTLFDH VTPDMRIYKE EIFGPVLSCV RVKDFGEAVD LINAHEFGNG
VSCFTSDGGI AREFARRIQV GMVGINVPIP VPMAWHGFGG WKKSLFGDMH AYGEEGVRFY
TRQKSVMQRW SSSIGKGAEF AMPTAK
//
