ID B9DTF5_STRU0 Unreviewed; 516 AA.
AC B9DTF5;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=SUB0279 {ECO:0000313|EMBL:CAR40812.1};
OS Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=218495 {ECO:0000313|EMBL:CAR40812.1, ECO:0000313|Proteomes:UP000000449};
RN [1] {ECO:0000313|Proteomes:UP000000449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-854 / 0140J {ECO:0000313|Proteomes:UP000000449};
RX PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA Parkhill J.;
RT "Evidence for niche adaptation in the genome of the bovine pathogen
RT Streptococcus uberis.";
RL BMC Genomics 10:54-54(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AM946015; CAR40812.1; -; Genomic_DNA.
DR RefSeq; WP_012657826.1; NC_012004.1.
DR AlphaFoldDB; B9DTF5; -.
DR SMR; B9DTF5; -.
DR STRING; 218495.SUB0279; -.
DR REBASE; 20069; M.SubORF279P.
DR KEGG; sub:SUB0279; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_0_1_9; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000000449; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CAR40812.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000449};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAR40812.1}.
FT DOMAIN 10..157
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 171..482
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 516 AA; 58203 MW; D7DAAA6E96B1F4A0 CRC64;
MSEQAQRQEL HSKIWKIADD VRGAVDGWDF KQYILGILFY RFISENFKNY MEAGDPNINY
ENVPESLITD DIKDDAVKTK GYFIMPNQLF SNIVKSARTN DNLNTDLKAI FDAIQASAIG
YESENDIKGL FDDVDTTSNR LGNTVPEKNK RLADILEGIA SLNFGHFEDN KIDLFGDAYE
YLISNYASNA GKSGGEFFTP QNVSKLLAKI VMLGRSESNK INKIYDPACG SGSLLLQAQK
QFTEHVIEDG FYGQEINLTT YNLARMNMFL HNINYDKFNI QRGDTLTDPK HGNDKPFDAI
VSNPPYSINW IGKDDPTLIN DDRFAPAGVL APKSKADFAF IMHSLSYLSA QGRAAIVVFP
GILYRGGAEQ KIRKYLVDNN FVEAIIQLPN NLFFGTSIAT CILVLAKNKT NTDTLFIDAS
AEFKKATNNN VLTEENIDKI LESIENKENK DYFAQVVPYE TIVEGDYNLS VSTYLEKEDT
REKIDIDVLN NEIKETVLKI DQLRLEIDKI VLDLSK
//
