ID B9DU91_STRU0 Unreviewed; 141 AA.
AC B9DU91;
DT 24-MAR-2009, integrated into UniProtKB/TrEMBL.
DT 24-MAR-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Galactose-6-phosphate isomerase subunit LacA {ECO:0000256|HAMAP-Rule:MF_01555};
DE EC=5.3.1.26 {ECO:0000256|HAMAP-Rule:MF_01555};
GN Name=lacA2 {ECO:0000313|EMBL:CAR41794.1};
GN Synonyms=lacA {ECO:0000256|HAMAP-Rule:MF_01555};
GN OrderedLocusNames=SUB0793 {ECO:0000313|EMBL:CAR41794.1};
OS Streptococcus uberis (strain ATCC BAA-854 / 0140J).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=218495 {ECO:0000313|EMBL:CAR41794.1, ECO:0000313|Proteomes:UP000000449};
RN [1] {ECO:0000313|Proteomes:UP000000449}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-854 / 0140J {ECO:0000313|Proteomes:UP000000449};
RX PubMed=19175920; DOI=10.1186/1471-2164-10-54;
RA Ward P.N., Holden M.T.G., Leigh J.A., Lennard N., Bignell A., Barron A.,
RA Clark L., Quail M.A., Woodward J., Barrell B.G., Egan S.A., Field T.R.,
RA Maskell D., Kehoe M., Dowson C.G., Chanter N., Whatmore A.M., Bentley S.D.,
RA Parkhill J.;
RT "Evidence for niche adaptation in the genome of the bovine pathogen
RT Streptococcus uberis.";
RL BMC Genomics 10:54-54(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=aldehydo-D-galactose 6-phosphate = keto-D-tagatose 6-
CC phosphate; Xref=Rhea:RHEA:13033, ChEBI:CHEBI:58255,
CC ChEBI:CHEBI:134283; EC=5.3.1.26; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_01555};
CC -!- PATHWAY: Carbohydrate metabolism; D-galactose 6-phosphate degradation;
CC D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1.
CC {ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- SUBUNIT: Heteromultimeric protein consisting of LacA and LacB.
CC {ECO:0000256|HAMAP-Rule:MF_01555}.
CC -!- SIMILARITY: Belongs to the LacAB/RpiB family.
CC {ECO:0000256|ARBA:ARBA00008754, ECO:0000256|HAMAP-Rule:MF_01555}.
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DR EMBL; AM946015; CAR41794.1; -; Genomic_DNA.
DR RefSeq; WP_000215993.1; NC_012004.1.
DR AlphaFoldDB; B9DU91; -.
DR STRING; 218495.SUB0793; -.
DR KEGG; sub:SUB0793; -.
DR eggNOG; COG0698; Bacteria.
DR HOGENOM; CLU_091396_4_2_9; -.
DR OrthoDB; 1778624at2; -.
DR UniPathway; UPA00702; UER00714.
DR Proteomes; UP000000449; Chromosome.
DR GO; GO:0050044; F:galactose-6-phosphate isomerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019388; P:galactose catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0019512; P:lactose catabolic process via tagatose-6-phosphate; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.1400.10; Sugar-phosphate isomerase, RpiB/LacA/LacB; 1.
DR HAMAP; MF_01555; LacA; 1.
DR InterPro; IPR004783; LacA.
DR InterPro; IPR003500; RpiB_LacA_LacB.
DR InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR NCBIfam; TIGR01118; lacA; 1.
DR NCBIfam; TIGR00689; rpiB_lacA_lacB; 1.
DR PANTHER; PTHR30345:SF5; GALACTOSE-6-PHOSPHATE ISOMERASE SUBUNIT LACA; 1.
DR PANTHER; PTHR30345; RIBOSE-5-PHOSPHATE ISOMERASE B; 1.
DR Pfam; PF02502; LacAB_rpiB; 1.
DR PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR SUPFAM; SSF89623; Ribose/Galactose isomerase RpiB/AlsB; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|HAMAP-Rule:MF_01555, ECO:0000313|EMBL:CAR41794.1};
KW Lactose metabolism {ECO:0000256|ARBA:ARBA00022736, ECO:0000256|HAMAP-
KW Rule:MF_01555}; Reference proteome {ECO:0000313|Proteomes:UP000000449}.
SQ SEQUENCE 141 AA; 15107 MW; 469EC4B6BE08A2E9 CRC64;
MTVIIGADKA GLELKEIVKS YLVELGHDVQ DVSAEGRDFV DTTLAVAKEV TANDVNLGIV
IDAYGVGSFM TATKIKGMIA AEVSDERSAY MTRGHNNSRI ITMGSEIVGP GVAKNIAKGF
VEGEYDGGRH QIRVDMLNKM C
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